喝咖啡对台湾成年人的骨骼健康有益处吗？一项纵向研究。
Does coffee drinking have beneficial effects on bone health of Taiwanese adults? A longitudinal study.
机构信息
Division of Family Medicine, Department of Community Medicine, Landseed Hospital, Taoyuan, Taiwan.
Department of Health Care Management, Chang Gung University, Taoyuan, Taiwan.
出版信息
BMC Public Health. 2018 Nov 20;18(1):1273. doi: 10.1186/s12889-018-6168-0.
BACKGROUND
Results from studies investigating the association between coffee consumption and osteoporosis or bone mineral density (BMD) have been inconsistent. This longitudinal study was performed to assess the effect of coffee drinking on bone health of Taiwanese adults.
METHODS
Data were retrieved from the Li-Shin (Landseed) Hospital in Taoyuan City. In 2006, 6152 participants completed a questionnaire on coffee drinking and other lifestyle factors. In 2014, 5077 of them were followed up. Nonetheless, a total of 2395 participants with incomplete data were excluded. The final analyses included 2682 participants comprising 1195 men and 1487 women (706 premenopausal and 781 postmenopausal). T-scores were derived from the osteo-sono assessment index (OSI) which is a surrogate of BMD. Coffee drinking was categorized as "no, medium, and high" based on the number of cups that were consumed per week in both 2006 and 2014.
RESULTS
In general, medium and high coffee drinking were associated with higher T-scores. However, significant results were observed only among high drinkers (β = 0.158; P = 0.0038). Nonetheless, the test for linear trend was significant (P = 0.0046). After stratification by sex, medium and high coffee drinking were associated with higher T-scores. However, significant results were prominent only among high male drinkers (β = 0.237; P = 0.0067) and the test for trend was significant (P = 0.0161). Based on menopausal status, coffee drinking was associated with higher T-scores. Nevertheless, significant results were found only among premenopausal women (β = 0.233; P = 0.0355 and β = 0.234; P = 0.0152 for medium and high coffee drinking, respectively. The test for linear trend was significant (P = 0.0108).
CONCLUSION
Coffee drinking was significantly associated with higher T-scores hence, a lower risk of osteoporosis in men and premenopausal women.
背景
关于喝咖啡与骨质疏松或骨密度（BMD）之间关系的研究结果并不一致。本纵向研究旨在评估喝咖啡对台湾成年人骨骼健康的影响。
方法
数据来自桃园市的坜新医院。2006 年，6152 名参与者完成了一份关于喝咖啡和其他生活方式因素的问卷。2014 年，其中 5077 人接受了随访。然而，共有 2395 名数据不完整的参与者被排除在外。最终分析包括 2682 名参与者，其中 1195 名男性和 1487 名女性（706 名绝经前和 781 名绝经后）。T 评分是通过骨声速评估指数（OSI）得出的，OSI 是 BMD 的替代指标。根据 2006 年和 2014 年每周饮用的杯数，将喝咖啡分为“不喝、中量和大量”。
结果
一般来说，中量和大量喝咖啡与较高的 T 评分相关。然而，仅在大量饮酒者中观察到显著结果（β=0.158；P=0.0038）。然而，线性趋势检验具有统计学意义（P=0.0046）。按性别分层后，中量和大量喝咖啡与较高的 T 评分相关。然而，仅在大量男性饮酒者中观察到显著结果（β=0.237；P=0.0067），且趋势检验具有统计学意义（P=0.0161）。根据绝经状态，喝咖啡与较高的 T 评分相关。然而，仅在绝经前女性中观察到显著结果（β=0.233；P=0.0355 和β=0.234；P=0.0152 分别用于中量和大量喝咖啡），线性趋势检验具有统计学意义（P=0.0108）。
结论
喝咖啡与较高的 T 评分显著相关，因此，男性和绝经前女性骨质疏松的风险较低。
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