Panesar Satvinder, Neethirajan Suresh
BioNano Laboratory, School of Engineering, University of Guelph, Guelph, ON N1G 2W1 Canada.
Nanomicro Lett. 2016;8(3):204-220. doi: 10.1007/s40820-015-0079-8. Epub 2016 Jan 8.
Breast cancer affected 1.7 million people worldwide in 2012 and accounts for approximately 23.3 % of all cancers diagnosed in women. The disease is characterized by a genetic mutation, either inherited or resulting from environmental factors, that causes uncontrollable cellular growth of breast tissue or adjacent tissues. Current means of diagnosing this disease depend on the individual analyzing the results from bulky, highly technical, and expensive equipment that is not globally accessible. As a result, patients can go undiagnosed due to a lack of available equipment or be over-diagnosed due to human error. This review attempts to highlight current means of diagnosing breast cancer and critically analyze their effectiveness and usefulness in terms of patient survival. An alternative means based on microfluidics biomarker detection is then presented. This method can be considered as a primary screening tool for diagnosing breast cancer based on its robustness, high throughput, low energy requirements, and accessibility to the general public.
2012年,全球有170万人罹患乳腺癌,约占女性确诊癌症总数的23.3%。该疾病的特征是基因突变,这种突变要么是遗传的,要么是由环境因素导致的,会引起乳腺组织或邻近组织的细胞不受控制地生长。目前诊断这种疾病的方法依赖于个人对大型、高技术且昂贵设备的检测结果进行分析,而这些设备并非全球都能获取。因此,患者可能因缺乏可用设备而未被诊断出来,或者因人为失误而被过度诊断。本综述试图突出当前乳腺癌的诊断方法,并从患者生存的角度批判性地分析其有效性和实用性。随后介绍了一种基于微流控生物标志物检测的替代方法。基于其稳健性、高通量、低能量需求以及对公众的可及性,这种方法可被视为诊断乳腺癌的一种初步筛查工具。