Karl Landsteiner Institute for Neuroimmunological and Neurodegenerative Disorders, Sozialmedizinisches Zentrum Ost - Donauspital, Vienna, Austria.
Center for Medical Statistics, Informatics and Intelligent Systems, Medical University Vienna, Vienna, Austria.
Mult Scler. 2019 Dec;25(14):1870-1877. doi: 10.1177/1352458518810924. Epub 2018 Nov 22.
The month-of-birth-effect (MoBE) describes the finding that multiple sclerosis (MS) patients seem to have been born significantly more frequently in spring, with a rise in May, and significantly less often in autumn and winter with the fewest births in November.
To analyse if the MoBE can also be found in the Austrian MS population, and if so, whether the pattern is similar to the reported pattern in Canada, United Kingdom, and some Scandinavian countries.
The data of 7886 MS patients in Austria were compared to all live births in Austria from 1940 to 2010, that is, 7.256545 data entries of the Austrian birth registry and analysed in detail.
Patterns observed in our MS cohort were not different from patterns in the general population, even when stratifying for gender. However, the noticeable and partly significant ups and downs over the examined years did not follow the distinct specific pattern with highest birth rates in spring and lowest birth rates in autumn that has been described previously for countries above the 49th latitude.
After correcting for month-of-birth patterns in the general Austrian population, there is no evidence for the previously described MoBE in Austrian MS patients.
出生月份效应（MoBE）描述了这样一种发现，多发性硬化症（MS）患者似乎更频繁地在春季出生，五月份出生的人数增加，而在秋季和冬季出生的人数较少，其中 11 月出生的人数最少。
分析 MoBE 是否也存在于奥地利的 MS 人群中，如果存在，其模式是否与加拿大、英国和一些斯堪的纳维亚国家报告的模式相似。
将奥地利 7886 名 MS 患者的数据与 1940 年至 2010 年期间奥地利所有活产儿的数据进行比较，即对奥地利出生登记处的 7.256545 个数据条目进行了详细分析。
我们的 MS 队列中观察到的模式与一般人群中的模式没有差异，即使按性别分层也是如此。然而，在过去的几年中，明显且部分显著的起伏并没有遵循以前描述的在 49 度纬度以上的国家中春季出生率最高、秋季出生率最低的特定模式。
在对奥地利一般人群的出生月份模式进行校正后，奥地利 MS 患者中没有证据表明存在以前描述的 MoBE。
