Wenzhou Medical University,The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, The Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, Wenzhou, China.
Biosci Rep. 2018 Dec 21;38(6). doi: 10.1042/BSR20181264.
Gastric cancer (GC) is the second most frequent cause of cancer-related mortality in the world, with Eastern Asia having the highest incidence rates. E2F is a family of transcription factor proteins that has a variety of functions, which include control of cell cycle, cell differentiation, DNA damage response and cell death. E2F transcription factors are divided into two subfamilies: transcription activators (E2F transcription factors 1 (E2F1), 2 (E2F2) and 3a (E2F3a)) and repressors (E2F3b, E2F transcription factors 4 (E2F4), 5 (E2F5), 6 (E2F6), 7 (E2F7) and 8 (E2F8)). Studies have demonstrated that E2F had prognostic significance in a number of cancers. However, the entirety of the prognostic roles of mRNA expression in GC has not yet been apparently determined. In the present study, the prognostic value of individual family members of mRNA expression for overall survival (OS) was evaluated by using online Kaplan-Meier Plotter (KM Plotter) database. Our result demonstrated that high expressions of three family members of E2F (E2F1, E2F3, E2F4) mRNA were significantly associated with unfavourable OS in all GC patients. However, increased expressions of E2F2, E2F5, E2F6 and E2F7 were significantly associated with favourable OS, especially for higher clinical stages in GC patients. These results provided a better insight into the prognostic functions of mRNA genes in GC. Although the results should be further verified in clinical trials, our findings may be a favourable prognostic predictor for the development of newer therapeutic drugs in the treatment of GC.
胃癌（GC）是全球第二大癌症相关死亡原因，东亚地区的发病率最高。E2F 是转录因子蛋白家族，具有多种功能，包括控制细胞周期、细胞分化、DNA 损伤反应和细胞死亡。E2F 转录因子分为两个亚家族：转录激活剂（E2F 转录因子 1（E2F1）、2（E2F2）和 3a（E2F3a））和抑制剂（E2F3b、E2F 转录因子 4（E2F4）、5（E2F5）、6（E2F6）、7（E2F7）和 8（E2F8））。研究表明，E2F 在多种癌症中具有预后意义。然而，E2F mRNA 表达的全部预后作用尚未明显确定。在本研究中，通过在线 Kaplan-Meier Plotter（KM Plotter）数据库评估了 E2F mRNA 表达的单个家族成员对总生存期（OS）的预后价值。我们的结果表明，E2F 的三个家族成员（E2F1、E2F3、E2F4）mRNA 的高表达与所有 GC 患者的不良 OS 显著相关。然而，E2F2、E2F5、E2F6 和 E2F7 的表达增加与良好的 OS 显著相关，特别是在 GC 患者的较高临床分期中。这些结果为 GC 中 E2F mRNA 基因的预后功能提供了更深入的了解。尽管这些结果应在临床试验中进一步验证，但我们的研究结果可能是开发治疗 GC 的新型治疗药物的有利预后预测指标。
