CRISPR-SURF：通过 CRISPR 平铺筛选数据的反卷积来发现调控元件。
CRISPR-SURF: discovering regulatory elements by deconvolution of CRISPR tiling screen data.
机构信息
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Molecular Pathology Unit, Center for Cancer Research, Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, MA, USA.
出版信息
Nat Methods. 2018 Dec;15(12):992-993. doi: 10.1038/s41592-018-0225-6.
Abstract
Further information on research design is available in the Nature Research Reporting Summary linked to this article.
摘要
更多关于研究设计的信息可在本文关联的 Nature 研究报告摘要中获取。
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Nature. 2017 Sep 7;549(7670):111-115. doi: 10.1038/nature23875. Epub 2017 Aug 30.
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CRISPR-Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome.CRISPR-Cas9表观基因组编辑可实现对人类基因组中功能调控元件的高通量筛选。
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High-resolution interrogation of functional elements in the noncoding genome.非编码基因组中功能元件的高分辨率分析。
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