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CRISPR-SURF: discovering regulatory elements by deconvolution of CRISPR tiling screen data.
Nat Methods. 2018 Dec;15(12):992-993. doi: 10.1038/s41592-018-0225-6.
2
Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9.
Nat Biotechnol. 2016 Feb;34(2):192-8. doi: 10.1038/nbt.3450. Epub 2016 Jan 11.
3
The dark side of the human genome.
Nature. 2016 Oct 13;538(7624):275-277. doi: 10.1038/538275a.
4
CRISPR-Cas system: a powerful tool for genome engineering.
Plant Mol Biol. 2014 Jun;85(3):209-18. doi: 10.1007/s11103-014-0188-7. Epub 2014 Mar 18.
5
CRISPR-based methods for high-throughput annotation of regulatory DNA.
Curr Opin Biotechnol. 2018 Aug;52:32-41. doi: 10.1016/j.copbio.2018.02.004. Epub 2018 Feb 28.
6
CRISPR-Cas9: A Precise Approach to Genome Engineering.
Ther Innov Regul Sci. 2018 Nov;52(6):701-707. doi: 10.1177/2168479018762798. Epub 2018 Apr 2.
7
Gene editing at CRISPR speed.
Nat Biotechnol. 2014 Apr;32(4):309-12. doi: 10.1038/nbt.2863.
8
Genomics: CRISPR engineering turns on genes.
Nature. 2015 Jan 29;517(7536):560-2. doi: 10.1038/517560a.
9
Engineering 3D genome organization.
Nat Rev Genet. 2021 Jun;22(6):343-360. doi: 10.1038/s41576-020-00325-5. Epub 2021 Feb 8.
10
Genome-Wide CRISPR/Cas9 Screening for Identification of Cancer Genes in Cell Lines.
Methods Mol Biol. 2019;1907:125-136. doi: 10.1007/978-1-4939-8967-6_10.

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Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells.
Cell Stem Cell. 2025 Feb 6;32(2):191-208.e11. doi: 10.1016/j.stem.2024.11.001. Epub 2024 Dec 12.
2
Decoding the epigenetics and chromatin loop dynamics of androgen receptor-mediated transcription.
Nat Commun. 2024 Nov 3;15(1):9494. doi: 10.1038/s41467-024-53758-5.
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SpRY-mediated screens facilitate functional dissection of non-coding sequences at single-base resolution.
Cell Genom. 2024 Jul 10;4(7):100583. doi: 10.1016/j.xgen.2024.100583. Epub 2024 Jun 17.
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Induced pluripotent stem cells (iPSCs): molecular mechanisms of induction and applications.
Signal Transduct Target Ther. 2024 Apr 26;9(1):112. doi: 10.1038/s41392-024-01809-0.
6
Machine learning methods for predicting guide RNA effects in CRISPR epigenome editing experiments.
bioRxiv. 2024 Apr 19:2024.04.18.590188. doi: 10.1101/2024.04.18.590188.
7
Multicenter integrated analysis of noncoding CRISPRi screens.
Nat Methods. 2024 Apr;21(4):723-734. doi: 10.1038/s41592-024-02216-7. Epub 2024 Mar 19.
8
Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma.
Nat Genet. 2023 Dec;55(12):2189-2199. doi: 10.1038/s41588-023-01551-3. Epub 2023 Nov 9.
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Integrative Enhancer Discovery Reveals a New Model of Enhancer Organization.
bioRxiv. 2023 Sep 21:2023.09.20.558459. doi: 10.1101/2023.09.20.558459.
10
UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability.
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本文引用的文献

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Discovery of stimulation-responsive immune enhancers with CRISPR activation.
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Science. 2016 Sep 30;353(6307):1545-1549. doi: 10.1126/science.aaf7613.
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Systematic mapping of functional enhancer-promoter connections with CRISPR interference.
Science. 2016 Nov 11;354(6313):769-773. doi: 10.1126/science.aag2445. Epub 2016 Sep 29.
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Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9.
Nat Biotechnol. 2016 Feb;34(2):192-8. doi: 10.1038/nbt.3450. Epub 2016 Jan 11.
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BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis.
Nature. 2015 Nov 12;527(7577):192-7. doi: 10.1038/nature15521. Epub 2015 Sep 16.
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Functional footprinting of regulatory DNA.
Nat Methods. 2015 Oct;12(10):927-30. doi: 10.1038/nmeth.3554. Epub 2015 Aug 31.
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An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level.
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