Kaneko Junichi, Kokudo Takashi, Inagaki Yoshinori, Hasegawa Kiyoshi
Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Division of Artificial Organ and Transplantation, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Transl Gastroenterol Hepatol. 2018 Oct 22;3:78. doi: 10.21037/tgh.2018.10.04. eCollection 2018.
Indocyanine green (ICG) is not new in the field of liver surgery. Early studies performed in the 1980s and 1990s revealed the value of the ICG clearance test in predicting post-hepatectomy morbidity and mortality. ICG clearance and retention tests are crucial for determining precise liver function before liver surgery and offer several benefits for safe surgery. Whereas ICG is well-known and has long history in medicine, recent progress in infrared light technology over the last decade has highlighted another feature of ICG. For example, ICG fluorescence-guided surgery may change the next generation of liver surgery. In the near future, ICG with near-infrared (NIR) light photodynamic therapy (PDT) is expected to become a new treatment method for hepatocellular carcinoma (HCC). Furthermore, several aspects of the mechanisms of ICG accumulation in HCC cells have been revealed by important basic research studies. New imaging technologies and mechanistic findings keep ICG in the spotlight. In this article, we review three recently described topics of ICG which may contribute to the development of innovative and new treatments method for HCC, fluorescence-guided surgery, mechanism of ICG accumulation in HCC cells, PDT for HCC.
吲哚菁绿（ICG）在肝脏外科领域并非新鲜事物。20世纪80年代和90年代进行的早期研究揭示了ICG清除试验在预测肝切除术后发病率和死亡率方面的价值。ICG清除和潴留试验对于在肝脏手术前确定精确的肝功能至关重要，并且为安全手术提供了诸多益处。尽管ICG在医学领域广为人知且历史悠久，但过去十年中红外光技术的最新进展突出了ICG的另一个特性。例如，ICG荧光引导手术可能会改变下一代肝脏手术。在不久的将来，ICG联合近红外（NIR）光动力疗法（PDT）有望成为肝细胞癌（HCC）的一种新的治疗方法。此外，重要的基础研究已经揭示了ICG在HCC细胞中蓄积机制的几个方面。新的成像技术和机制研究结果使ICG备受关注。在本文中，我们综述了最近描述的关于ICG的三个主题，它们可能有助于开发针对HCC的创新和新的治疗方法，即荧光引导手术、ICG在HCC细胞中的蓄积机制、HCC的PDT。
