Permin H, Hørbov S, Wiik A, Knudsen J V
Acta Paediatr Scand. 1978 Mar;67(2):181-5. doi: 10.1111/j.1651-2227.1978.tb16300.x.
One hundred patients with juvenile chronic arthritis (JCA) were studied with respect to granulocyte-specific and organ-nonspecific antinuclear antibodies (GS- and ON-ANA) in relation to clinical features of disease. Seventy-two were girls and 28 boys. Sixty-seven patients had IgG ANA, 31 IgM, 10 IgA, 6 IgD, 19 IgE and 35 had ANA, which fixed complement C3. Sixteen of 17 sera containing IgG GS-ANA were from girls. The prevalence of IgG GS-ANA increased with the number of joints affected. No patient with the acute febrile type of the disease had IgG GS-ANA or CS fixing ANA. The prevalence of IgG ON-ANA did not differ significantly in the mono-, pauci-, polyarticular and acute febrile types of JCA. Patients showing clinical activity more frequently had IgG and IgM ANA and C3 fixing ANA. The high titers of ANA were most often seen in girls. Chronic uveitis occurred in 10 of the patients and IgG ANA were present in sera from all of these.
对100例青少年慢性关节炎（JCA）患者进行了研究，检测其粒细胞特异性和器官非特异性抗核抗体（GS-ANA和ON-ANA），并分析这些抗体与疾病临床特征的关系。其中72例为女孩，28例为男孩。67例患者有IgG ANA，31例有IgM，10例有IgA，6例有IgD，19例有IgE，35例有可固定补体C3的ANA。17份含有IgG GS-ANA的血清中有16份来自女孩。IgG GS-ANA的患病率随受累关节数量的增加而升高。急性发热型疾病患者均无IgG GS-ANA或可固定补体的ANA。IgG ON-ANA在JCA的单关节型、少关节型、多关节型和急性发热型中的患病率无显著差异。临床表现为活动期的患者更常出现IgG和IgM ANA以及可固定补体C3的ANA。ANA高滴度多见于女孩。10例患者发生慢性葡萄膜炎，所有这些患者的血清中均存在IgG ANA。
