Department of Biochemistry, Microbiology and Biotechnology, Faculty of Biology, Yerevan State University, 0025 Yerevan, Armenia.
Biomed Res Int. 2018 Nov 7;2018:4526352. doi: 10.1155/2018/4526352. eCollection 2018.
Diabetes mellitus (DM) is a serious chronic metabolic disorder. Various diseases are being treated with medicinal plants and that is because of the less side effects of the current therapy. The diversity of plants in Armenia is due to the singularity of natural environment. However, biochemical activity of these plants has not been studied well. Thus, the goal was to investigate biochemical activity and antihyperglycemic properties of L. in rabbits with hyperglycemia. The high content of total phenolic compounds, flavonoids, and tannins has been determined in this plant extract. Oral administration of ethanol extract showed significant effect on hyperglycemia, reducing fasting glucose levels (57.3%, p<0.05), improving glucose tolerance, and increasing liver glycogen content (1.5-fold, p<0.01) compared to the hyperglycemic control group. Furthermore, ethanol extract of reduced total cholesterol, low-density lipoprotein cholesterol levels, and vice versa increased high-density lipoprotein cholesterol levels and also decreased liver enzymes levels (alanine aminotransferase and aspartate aminotransferase) compared with untreated group. These findings suggest that may have beneficial effects and should be supplement, as herbal remedy in the treatment of DM.
糖尿病（DM）是一种严重的慢性代谢紊乱。各种疾病都在用药用植物进行治疗，这是因为目前的治疗方法副作用较小。亚美尼亚的植物多样性是由于其自然环境的独特性造成的。然而，这些植物的生化活性尚未得到很好的研究。因此，本研究的目的是研究 L. 在患有高血糖症的兔子中的生化活性和降血糖作用。该植物提取物中含有丰富的总酚类化合物、类黄酮和单宁。与高血糖对照组相比，乙醇提取物的口服给药对高血糖有显著影响，降低空腹血糖水平（57.3%，p<0.05），改善葡萄糖耐量，并增加肝糖原含量（1.5 倍，p<0.01）。此外，与未治疗组相比， 乙醇提取物还降低了总胆固醇、低密度脂蛋白胆固醇水平，反之增加了高密度脂蛋白胆固醇水平，同时还降低了肝酶水平（丙氨酸氨基转移酶和天冬氨酸氨基转移酶）。这些发现表明， 可能具有有益的作用，应该作为治疗 DM 的草药补充剂。
