Yuan Feng-Lai, Wu Qian-Yuan, Miao Zong-Ning, Xu Ming-Hui, Xu Rui-Sheng, Jiang Dong-Lin, Ye Jun-Xing, Chen Fei-Hu, Zhao Ming-Dong, Wang Hao-Jue, Li Xia
Department of Orthopaedics and Central Laboratory, The Third Hospital Affiliated to Nantong University, Wuxi, China.
Department of Pediatrics, People's Hospital of Puyang, Puyang, China.
Front Physiol. 2018 May 30;9:628. doi: 10.3389/fphys.2018.00628. eCollection 2018.
Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, play an important role in cellular communication during skeletal growth and homeostasis. Bioactive molecules carried by EVs are transported to neighboring and distant cells to trigger a series of signaling cascades influencing bone homeostasis. The bioactive activities of osteoclast-derived EVs include regulation of osteoclastogenesis and osteoclast-osteoblast communication. As osteoclast-derived EVs have the potential to regulate osteoclasts and osteoblasts, their application in osteoporosis and other bone metabolic disorders is currently under investigation. However, very few reviews of osteoclast-derived EVs in bone remodeling regulation have yet been published. This article aims to review recent advances in this field, summarizing a new regulator of osteoclastogenesis and osteoclast-osteoblast communication mediated by osteoclast-derived EVs. We will analyze the major challenges in the field and potential for the therapeutic application of EVs.
细胞外囊泡（EVs），包括外泌体、微囊泡和凋亡小体，在骨骼生长和体内平衡过程中的细胞通讯中发挥着重要作用。EVs携带的生物活性分子被转运到邻近和远处的细胞，以触发一系列影响骨稳态的信号级联反应。破骨细胞衍生的EVs的生物活性包括调节破骨细胞生成和破骨细胞-成骨细胞通讯。由于破骨细胞衍生的EVs具有调节破骨细胞和成骨细胞的潜力，它们在骨质疏松症和其他骨代谢疾病中的应用目前正在研究中。然而，关于破骨细胞衍生的EVs在骨重塑调节方面的综述很少发表。本文旨在综述该领域的最新进展，总结由破骨细胞衍生的EVs介导的破骨细胞生成和破骨细胞-成骨细胞通讯的新调节因子。我们将分析该领域的主要挑战以及EVs治疗应用的潜力。
