Gonzalez Antonio J, Berr Stuart S, Cañizares Gabriel, Gonzalez-Montoro Andrea, Orero Abel, Correcher Carlos, Rezaei Ahmadreza, Nuyts Johan, Sanchez Filomeno, Majewski Stan, Benlloch Jose M
Detector for Molecular Imaging Lab (DMIL), Instituto de Instrumentacion para Imagen Molecular (i3M), Centro Mixto CSIC - Universitat Politècnica de València, Valencia, Spain.
Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States.
Front Med (Lausanne). 2018 Nov 28;5:328. doi: 10.3389/fmed.2018.00328. eCollection 2018.
There are drawbacks with using a Positron Emission Tomography (PET) scanner design employing the traditional arrangement of multiple detectors in an array format. Typically PET systems are constructed with many regular gaps between the detector modules in a ring or box configuration, with additional axial gaps between the rings. Although this has been significantly reduced with the use of the compact high granularity SiPM photodetector technology, such a scanner design leads to a decrease in the number of annihilation photons that are detected causing lower scanner sensitivity. Moreover, the ability to precisely determine the line of response (LOR) along which the positron annihilated is diminished closer to the detector edges because the spatial resolution there is degraded due to edge effects. This happens for both monolithic based designs, caused by the truncation of the scintillation light distribution, but also for detector blocks that use crystal arrays with a number of elements that are larger than the number of photosensors and, therefore, make use of the light sharing principle. In this report we present a design for a small-animal PET scanner based on a single monolithic annulus-like scintillator that can be used as a PET insert in high-field Magnetic Resonance systems. We provide real data showing the performance improvement when edge-less modules are used. We also describe the specific proposed design for a rodent scanner that employs facetted outside faces in a single LYSO tube. In a further step, in order to support and prove the proposed edgeless geometry, simulations of that scanner have been performed and lately reconstructed showing the advantages of the design.
采用传统的阵列格式排列多个探测器的正电子发射断层扫描(PET)扫描仪设计存在一些缺点。通常,PET系统在环形或盒形配置中,探测器模块之间存在许多规则间隙,环之间还有额外的轴向间隙。尽管使用紧凑的高粒度硅光电倍增管(SiPM)光电探测器技术已显著减少了这种间隙,但这种扫描仪设计会导致探测到的湮灭光子数量减少,从而降低扫描仪的灵敏度。此外,由于边缘效应导致那里的空间分辨率下降,靠近探测器边缘时,精确确定正电子湮灭所沿响应线(LOR)的能力会减弱。对于基于整块的设计,由于闪烁光分布的截断会出现这种情况;对于使用晶体阵列且晶体元件数量大于光电传感器数量并因此利用光共享原理的探测器模块,也会出现这种情况。在本报告中,我们展示了一种基于单个整块环形闪烁体的小动物PET扫描仪设计,该设计可作为PET插入件用于高场磁共振系统。我们提供了实际数据,展示了使用无边缘模块时性能的提升。我们还描述了一种针对啮齿动物扫描仪的具体设计方案,该方案在单个LYSO管中采用了多面外表面。进一步地,为了支持和验证所提出的无边缘几何结构,已对该扫描仪进行了模拟,并最终重建结果展示了该设计的优势。