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长链非编码 RNA CTD-2510F5.4 在胃癌中的预后及临床病理意义。

Prognostic and clinicopathological significance of long noncoding RNA CTD-2510F5.4 in gastric cancer.

机构信息

Medical Oncology Department of Gastrointestinal Cancer (1), Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, NO.44 Xiaoheyan Road, Dadong District, Shenyang, 110042, Liaoning, People's Republic of China.

出版信息

Gastric Cancer. 2019 Jul;22(4):692-704. doi: 10.1007/s10120-018-00911-x. Epub 2018 Dec 17.

DOI:10.1007/s10120-018-00911-x
PMID:30560474
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6570689/
Abstract

BACKGROUND

Compelling studies have demonstrated the correlation between aberrant expressed lncRNAs and human cancers, and revealed promise of these lncRNAs as biomarkers in predicting patients' survival and outcome.

METHODS

We downloaded the RNA-seq data from the Cancer Genome Atlas, and screened out DEGs and DELs between gastric cancer tissues and normal gastric tissues. By bioinformatics analysis, we identified CTD-2510F5.4 was a malignant phenotype associated lncRNA. The expression levels of CTD-2510F5.4 in tissues were detected by ISH, and the relationships between CTD-2510F5.4 expression and clinicopathological characteristics were analyzed by statistical analysis.

RESULTS

By bioinformatics analysis and functional analysis, we identified CTD-2510F5.4 was a malignant phenotype associated lncRNA of gastric cancer that potentially regulated cell cycle and apoptosis. CTD-2510F5.4 expression was significantly higher in gastric cancers, and was correlated with pathological grade, vascular or nerve invasion, AJCC TNM stage and OS. Moreover, gastric cancer patients with high CTD-2510F5.4 expression showed significantly shorter MST. High CTD-2510F5.4 expression was a independent risk factor for gastric cancers at pathological grade < III and without vascular or nerve invasion.

CONCLUSIONS

We identified CTD-2510F5.4 was a malignant phenotype associated lncRNA potentially involved in the pathogenesis of gastric cancer. Our data also supported the clinical potential of CTD-2510F5.4 being a diagnostic and prognostic biomarker for gastric cancer.

摘要

背景

大量研究表明，异常表达的长链非编码 RNA 与人类癌症之间存在相关性，并揭示了这些 lncRNA 作为预测患者生存和预后的生物标志物的潜力。

方法

我们从癌症基因组图谱中下载了 RNA-seq 数据，并筛选出胃癌组织和正常胃组织之间的差异表达基因和差异外显子。通过生物信息学分析，我们鉴定出 CTD-2510F5.4 是一种与恶性表型相关的 lncRNA。通过原位杂交检测组织中 CTD-2510F5.4 的表达水平，并通过统计学分析分析 CTD-2510F5.4 表达与临床病理特征的关系。

结果

通过生物信息学分析和功能分析，我们鉴定出 CTD-2510F5.4 是一种与胃癌恶性表型相关的 lncRNA，可能调节细胞周期和凋亡。CTD-2510F5.4 在胃癌中的表达明显升高，与病理分级、血管或神经侵犯、AJCC TNM 分期和 OS 相关。此外，CTD-2510F5.4 高表达的胃癌患者 MST 明显缩短。CTD-2510F5.4 高表达是病理分级<III 且无血管或神经侵犯的胃癌的独立危险因素。

结论

我们鉴定出 CTD-2510F5.4 是一种与胃癌恶性表型相关的 lncRNA，可能参与胃癌的发病机制。我们的数据还支持 CTD-2510F5.4 作为胃癌诊断和预后生物标志物的临床潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aef/6570689/c8c6bb951589/10120_2018_911_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aef/6570689/4b90b6d2ebef/10120_2018_911_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aef/6570689/31b7b5dd7008/10120_2018_911_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aef/6570689/f589f5fb229e/10120_2018_911_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aef/6570689/2c835f877a0d/10120_2018_911_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aef/6570689/c8c6bb951589/10120_2018_911_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aef/6570689/4b90b6d2ebef/10120_2018_911_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aef/6570689/31b7b5dd7008/10120_2018_911_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aef/6570689/f589f5fb229e/10120_2018_911_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aef/6570689/2c835f877a0d/10120_2018_911_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aef/6570689/c8c6bb951589/10120_2018_911_Fig5_HTML.jpg

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