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伊朗疟疾流行区库蚊（双翅目：蚊科）对氟氯氰菊酯和滴滴涕抗性的生化基础

Biochemical Basis of Cyfluthrin and DDT Resistance in (Diptera: Culicidae) in Malarious Area of Iran.

作者信息

Gorouhi Mohammad Amin, Oshaghi Mohammad Ali, Vatandoost Hassan, Enayati Ahmad Ali, Raeisi Ahmad, Abai Mohamad Reza, Salim-Abadie Yaser, Hanafi-Bojd Ahmad Ali, Paksa Azim, Nikpoor Fatemeh

机构信息

Department of Vector Biology and Control, School of Health, Kerman University of Medical Sciences, Kerman, Iran.

Department of Medical Entomology and Vector Control, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

J Arthropod Borne Dis. 2018 Sep 30;12(3):310-320. eCollection 2018 Sep.

PMID:30584554
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6297723/
Abstract

BACKGROUND

is a key urban malaria vector in the Indian subcontinent and Middle East including south and southeast of Iran. Wide application of insecticides resulted in resistance of this species to various insecticides in these regions. This study was conducted to reveal the role of metabolic mechanisms in the development of resistance in to DDT and cyfluthrin.

METHODS

Field mosquito specimens were collected from Chabahar Seaport, southeast corner of Iran, in 2015. Insecticide susceptibility and enzyme assays were conducted as recommended by WHO.

RESULTS

Mean enzyme ratios were 3.95 and 3.04 for α- esterases and 2.40 and 1.97 for β- esterases in the DDT and cyfluthrin- resistant populations correspondingly compared with the susceptible strain. The GSTs enzyme mean activity ratios were 5.07 and 2.55 in the DDT and cyfluthrin- resistant populations compared with the susceptible beech strain. The cytochrome p450s enzyme ratios were 1.11 and 1.28 in the DDT and cyfluthrin- resistant populations respectively compared with the susceptible beech strain.

CONCLUSION

Metabolic mechanisms play a crucial role in the development of DDT and cyfluthrin resistance in , therefore, further evaluation of the mechanisms involved as well as implementation of proper insecticide resistance management strategies are recommended.

摘要

背景

在印度次大陆和中东地区（包括伊朗南部和东南部）是主要的城市疟疾传播媒介。杀虫剂的广泛使用导致该物种在这些地区对各种杀虫剂产生抗性。本研究旨在揭示代谢机制在对滴滴涕和氟氯氰菊酯抗性发展中的作用。

方法

2015年从伊朗东南角的恰巴哈尔港采集野外蚊虫标本。按照世界卫生组织的建议进行杀虫剂敏感性和酶活性测定。

结果

与敏感品系相比，滴滴涕抗性种群中α-酯酶的平均酶活性比为3.95，β-酯酶为3.04；氟氯氰菊酯抗性种群中α-酯酶的平均酶活性比为2.40，β-酯酶为1.97。与敏感品系相比，滴滴涕抗性种群中谷胱甘肽S-转移酶（GSTs）的平均酶活性比为5.07，氟氯氰菊酯抗性种群中为2.55。与敏感品系相比，滴滴涕抗性种群中细胞色素P450s的酶活性比为1.11，氟氯氰菊酯抗性种群中为1.28。

结论

代谢机制在对滴滴涕和氟氯氰菊酯抗性的发展中起关键作用，因此，建议进一步评估相关机制并实施适当的杀虫剂抗性管理策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3959/6297723/62cb4bbdf4b8/JAD-12-310-g001.jpg

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