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2
Effect of surface alkali-based treatment of titanium implants on ability to promote in vitro mineralization and in vivo bone formation.钛种植体表面碱处理对体外矿化及体内骨形成促进能力的影响。
Acta Biomater. 2017 Jul 15;57:511-523. doi: 10.1016/j.actbio.2017.05.016. Epub 2017 May 9.
3
The influence of controlled surface nanotopography on the early biological events of osseointegration.可控表面纳米形貌对骨结合早期生物学事件的影响。
Acta Biomater. 2017 Apr 15;53:559-571. doi: 10.1016/j.actbio.2017.02.026. Epub 2017 Feb 21.
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Synergistic effect of nanotopography and bioactive ions on peri-implant bone response.纳米形貌与生物活性离子对种植体周围骨反应的协同作用。
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Tribological behavior of Ti6Al4V cellular structures produced by Selective Laser Melting.选择性激光熔化制备的Ti6Al4V多孔结构的摩擦学行为
J Mech Behav Biomed Mater. 2017 May;69:128-134. doi: 10.1016/j.jmbbm.2017.01.004. Epub 2017 Jan 4.
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A technique for evaluating bone ingrowth into 3D printed, porous Ti6Al4V implants accurately using X-ray micro-computed tomography and histomorphometry.一种利用X射线显微计算机断层扫描和组织形态计量学精确评估骨长入3D打印多孔Ti6Al4V植入物的技术。
Micron. 2017 Mar;94:1-8. doi: 10.1016/j.micron.2016.11.009. Epub 2016 Nov 21.
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激光诱导钛植入物的表面形态表征:增强骨整合过程的经验教训。

Surface morphology characterization of laser-induced titanium implants: lesson to enhance osseointegration process.

作者信息

Tavakoli Javad, Khosroshahi Mohammad E

机构信息

1Biomechanics and Implants Research Group, The Medical Device Research Institute, College of Science and Engineering, Flinders University, GPO Box 2100, Adelaide, SA 5001 Australia.

2Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON M5S 3G8 Canada.

出版信息

Biomed Eng Lett. 2018 Apr 4;8(3):249-257. doi: 10.1007/s13534-018-0063-6. eCollection 2018 Aug.

DOI:10.1007/s13534-018-0063-6
PMID:30603208
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6208542/
Abstract

The surface properties of implant are responsible to provide mechanical stability by creating an intimate bond between the bone and implant; hence, play a major role on osseointegration process. The current study was aimed to measure surface characteristics of titanium modified by a pulsed Nd:YAG laser. The results of this study revealed an optimum density of laser energy (140 Jcm), at which improvement of osteointegration process was seen. Significant differences were found between arithmetical mean height (Ra), root mean square deviation (Rq) and texture orientation, all were lower for 140 Jcm samples compared to untreated one. Also it was identified that the surface segments were more uniformly distributed with a more Gaussian distribution for treated samples at 140 Jcm. The distribution of texture orientation at high laser density (250 and 300 Jcm) were approximately similar to untreated sample. The skewness index that indicates how peaks and valleys are distributed throughout the surface showed a positive value for laser treated samples, compared to untreated one. The surface characterization revealed that Kurtosis index, which tells us how high or flat the surface profile is, for treated sample at 140 Jcm was marginally close to 3 indicating flat peaks and valleys in the surface profile.

摘要

植入物的表面特性通过在骨与植入物之间形成紧密结合来提供机械稳定性,因此在骨整合过程中起主要作用。当前的研究旨在测量经脉冲Nd:YAG激光改性的钛的表面特性。该研究结果显示了激光能量的最佳密度(140 J/cm²),在此密度下可观察到骨整合过程得到改善。在算术平均高度(Ra)、均方根偏差(Rq)和纹理方向方面发现了显著差异,与未处理的样品相比,140 J/cm²的样品在这些方面的值均较低。此外,还确定在140 J/cm²下处理的样品表面段分布更均匀,且具有更接近高斯分布的特征。在高激光密度(250和300 J/cm²)下的纹理方向分布与未处理的样品大致相似。与未处理的样品相比,表明表面峰谷分布情况的偏度指数在激光处理的样品中显示为正值。表面表征显示,对于140 J/cm²下处理的样品,反映表面轮廓高低或平坦程度的峰度指数略接近3,表明表面轮廓中的峰谷较为平坦。