Farzamfar Saeed, Naseri-Nosar Mahdi, Ghanavatinejad Alireza, Vaez Ahmad, Zarnani Amir Hassan, Salehi Majid
Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, 1417755469, Iran.
Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, 1417755469, Iran.
Mol Biol Rep. 2017 Oct;44(5):407-412. doi: 10.1007/s11033-017-4124-1. Epub 2017 Oct 4.
This is the first study demonstrating the efficacy of menstrual blood-derived stem cell (MenSC) transplantation via a neural guidance conduit, for peripheral nerve regeneration. The synthesized poly (ɛ-caprolactone)/Gelatin conduit, filled with collagen type I and seeded with 3 × 10 MenSCs, was implanted into a rat's 10 mm sciatic nerve defect. The results of hot plate latency, sciatic functional index and weight-loss percentage of wet gastrocnemius muscle demonstrated that the MenSC transplantation had comparable nerve regeneration outcome to autograft, as the gold standard of nerve bridging. The transplantation of MenSCs via a synthetic conduit could ameliorate the functional recovery of sciatic nerve-injured rats which make them a potential candidate for cell therapy of peripheral nervous system disorders.
这是第一项证明通过神经引导导管进行月经血源性干细胞（MenSC）移植以促进周围神经再生有效性的研究。将填充有I型胶原蛋白并接种3×10个MenSCs的合成聚（ε-己内酯）/明胶导管植入大鼠10毫米坐骨神经缺损处。热板潜伏期、坐骨神经功能指数和湿腓肠肌减重百分比的结果表明，作为神经桥接的金标准，MenSC移植具有与自体移植相当的神经再生效果。通过合成导管进行MenSCs移植可改善坐骨神经损伤大鼠的功能恢复，这使其成为周围神经系统疾病细胞治疗的潜在候选者。
