Bushell T E, Evans E G, Meaden J D, Milne J D, Warnock D W
Royal West Sussex Hospital, Chichester.
Genitourin Med. 1988 Oct;64(5):335-8. doi: 10.1136/sti.64.5.335.
Women with recurrent vaginal candidosis were treated until the infection cleared and were then given one clotrimazole 500 mg vaginal tablet a month or an identical placebo as prophylaxis. Of 21 women who received placebo, 16 developed symptoms or signs within three months, compared with nine of 17 women given active treatment. Women who relapsed were treated and then given active prophylaxis once a month. Of 30 women given such treatment, 13 relapsed within three months. Women who relapsed were treated and then given two clotrimazole 500 mg vaginal tablets a month. Of 17 women given prophylaxis twice a month, four developed symptoms or signs within three months, but 10 remained clear for 12 months. No appreciable difference was seen in the incidence of mycological recurrence between the different regimens; within three months over half the women in all treatment groups had become recolonised.
复发性阴道念珠菌病的女性患者接受治疗直至感染清除，然后每月给予一片500毫克克霉唑阴道片或相同的安慰剂作为预防措施。在接受安慰剂的21名女性中，16名在三个月内出现症状或体征，而接受积极治疗的17名女性中有9名出现症状或体征。复发的女性接受治疗，然后每月给予一次积极的预防措施。在接受这种治疗的30名女性中，13名在三个月内复发。复发的女性接受治疗，然后每月给予两片500毫克克霉唑阴道片。在每月接受两次预防措施的17名女性中，4名在三个月内出现症状或体征，但10名在12个月内保持无症状。不同治疗方案之间的真菌学复发率没有明显差异；在三个月内，所有治疗组中超过一半的女性再次感染。
