Fong I W, Bannatyne R M, Wong P
Department of Microbiology, St Michael's Hospital, University of Toronto, Ontario, Canada.
Genitourin Med. 1993 Feb;69(1):44-6. doi: 10.1136/sti.69.1.44.
To determine whether in vitro resistance of Candida albicans to the imidazoles (ketoconazole, clotrimazole and itraconazole) is associated with recurrence of candida vaginitis.
Candida isolates were collected before, during and after treatment from women with recurrent vaginal candidiasis (> or = 4 episodes/year), randomised into two prospective studies: (1) 56 women treated with ketoconazole 400 mg/daily for 7 days; (2) 44 women randomised to receive itraconazole 200 mg orally, or clotrimazole 200 mg intravaginally, twice weekly for six months.
Women's Candida Clinic at St. Michael's Hospital, a University of Toronto teaching Hospital, Toronto, Ontario, Canada. MAIN OUTCOME, MEASURES: Isolates of yeasts recovered pre and post treatment were tested for significant changes in 50% inhibitory concentration (IC50). Resistance was defined as a greater than fourfold increase in baseline IC50 of post treatment isolates compared with pretreatment isolates.
Over 250 strains of C albicans were tested and none showed development of resistance to any of the agents.
Recurrence of vaginal candidiasis is not related to the development of drug resistance.
确定白色念珠菌对咪唑类药物（酮康唑、克霉唑和伊曲康唑）的体外耐药性是否与念珠菌性阴道炎的复发有关。
从复发性阴道念珠菌病（每年发作≥4次）的女性患者治疗前、治疗期间和治疗后收集念珠菌分离株，随机分为两项前瞻性研究：（1）56名女性患者每天口服400mg酮康唑，持续7天；（2）44名女性患者随机接受口服200mg伊曲康唑或阴道内使用200mg克霉唑，每周两次，持续6个月。
加拿大安大略省多伦多市多伦多大学教学医院圣迈克尔医院的女性念珠菌诊所。主要观察指标：检测治疗前后分离出的酵母菌株的50%抑制浓度（IC50）是否有显著变化。耐药性定义为治疗后分离株的基线IC50与治疗前分离株相比增加超过四倍。
检测了超过250株白色念珠菌，没有一株显示出对任何一种药物产生耐药性。
阴道念珠菌病的复发与耐药性的产生无关。
