Institute of Integrative Biology, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK.
Institut Curie, 25 rue d'Ulm, 75005 Paris, France.
Nucleic Acids Res. 2019 Jan 8;47(D1):D1-D7. doi: 10.1093/nar/gky1267.
The 2019 Nucleic Acids Research (NAR) Database Issue contains 168 papers spanning molecular biology. Among them, 64 are new and another 92 are updates describing resources that appeared in the Issue previously. The remaining 12 are updates on databases most recently published elsewhere. This Issue contains two Breakthrough articles, on the Virtual Metabolic Human (VMH) database which links human and gut microbiota metabolism with diet and disease, and Vibrism DB, a database of mouse brain anatomy and gene (co-)expression with sophisticated visualization and session sharing. Major returning nucleic acid databases include RNAcentral, miRBase and LncRNA2Target. Protein sequence databases include UniProtKB, InterPro and Pfam, while wwPDB and RCSB cover protein structure. STRING and KEGG update in the section on metabolism and pathways. Microbial genomes are covered by IMG/M and resources for human and model organism genomics include Ensembl, UCSC Genome Browser, GENCODE and Flybase. Genomic variation and disease are well-covered by GWAS Catalog, PopHumanScan, OMIM and COSMIC, CADD being another major newcomer. Major new proteomics resources reporting here include iProX and jPOSTdb. The entire database issue is freely available online on the NAR website (https://academic.oup.com/nar). The NAR online Molecular Biology Database Collection has been updated, reviewing 506 entries, adding 66 new resources and eliminating 147 discontinued URLs, bringing the current total to 1613 databases. It is available at http://www.oxfordjournals.org/nar/database/c.
2019 年核酸研究 (NAR) 数据库专刊包含 168 篇论文，涵盖分子生物学领域。其中，有 64 篇是新论文，另外 92 篇是对先前专刊中出现过的资源的更新描述。其余 12 篇是对最近在其他地方发表的数据库的更新。本期专刊包含两篇突破性文章，一篇是关于虚拟代谢人体 (VMH) 数据库的文章，该数据库将人类和肠道微生物群的代谢与饮食和疾病联系起来；另一篇是关于 Vibrism DB 的文章，这是一个具有复杂可视化和会话共享功能的鼠标大脑解剖结构和基因（协同）表达数据库。主要回归的核酸数据库包括 RNAcentral、miRBase 和 LncRNA2Target。蛋白质序列数据库包括 UniProtKB、InterPro 和 Pfam，而 wwPDB 和 RCSB 则涵盖蛋白质结构。代谢和途径部分的 STRING 和 KEGG 更新。微生物基因组由 IMG/M 覆盖，人类和模式生物基因组资源包括 Ensembl、UCSC 基因组浏览器、GENCODE 和 Flybase。GWAS Catalog、PopHumanScan、OMIM 和 COSMIC 很好地涵盖了基因组变异和疾病，CADD 是另一个主要的新成员。这里报道的主要新蛋白质组学资源包括 iProX 和 jPOSTdb。整个数据库专刊可在 NAR 网站 (https://academic.oup.com/nar) 上免费在线获取。NAR 在线分子生物学数据库收藏已更新，共审查了 506 项条目，新增了 66 个新资源，并删除了 147 个已停用的 URL，目前总数达到 1613 个数据库。它可在 http://www.oxfordjournals.org/nar/database/c 上获得。
