School of Mathematics and Statistics, University of St Andrews, The Observatory, Buchanan Gardens, St Andrews, KY16 9LZ, UK.
School of Medicine, University of St Andrews, North Haugh, St Andrews, KY16 9TF, UK.
BMC Med Res Methodol. 2019 Jan 9;19(1):11. doi: 10.1186/s12874-018-0629-0.
A key element in the interaction between clinicians and patients with cancer is reassurance giving. Learning about the stochastic nature of reassurances as well as making inferential statements about the influence of covariates such as patient response and time spent on previous reassurances are of particular importance.
We fit Hidden Markov Models (HMMs) to reassurance type from multiple time series of clinicians' reassurances, decoded from audio files of review consultations between patients with breast cancer and their therapeutic radiographer. Assuming a latent state process driving the observations process, HMMs naturally accommodate serial dependence in the data. Extensions to the baseline model such as including covariates as well as allowing for fixed effects for the different clinicians are straightforward to implement.
We found that clinicians undergo different states, in which they are more or less inclined to provide a particular type of reassurance. The states are very persistent, however switches occasionally occur. The lengthier the previous reassurance, the more likely the clinician is to stay in the current state.
HMMs prove to be a valuable tool and provide important insights for practitioners.
Trial Registration number: ClinicalTrials.gov: NCT02599506. Prospectively registered on 11th March 2015.
临床医生与癌症患者互动的一个关键要素是给予安慰。了解安慰的随机性,并对患者反应和之前给予安慰所花费的时间等协变量的影响做出推断性陈述,尤为重要。
我们对来自多个时间序列的安慰类型拟合了隐马尔可夫模型(HMMs),这些时间序列是从乳腺癌患者与他们的治疗放射技师的审查咨询的音频文件中解码出来的。假设潜在状态过程驱动观测过程,HMMs 自然适应数据中的序列依赖性。扩展基线模型,例如包括协变量以及允许不同临床医生的固定效应,实施起来非常简单。
我们发现,临床医生经历不同的状态,在这些状态中,他们更倾向于提供某种类型的安慰。这些状态非常持久,但偶尔会发生转变。之前的安慰时间越长,临床医生越有可能保持当前状态。
HMMs 被证明是一种有价值的工具,为从业者提供了重要的见解。
试验注册号:ClinicalTrials.gov:NCT02599506。于 2015 年 3 月 11 日前瞻性注册。