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用于转化癌症研究的质量保证研究环境。

Quality-assured research environments for translational cancer research.

机构信息

Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

出版信息

Mol Oncol. 2019 Mar;13(3):543-548. doi: 10.1002/1878-0261.12441. Epub 2019 Feb 22.

Abstract

In order to secure high-quality cancer care for increasing numbers of cancer patients in the upcoming decades, the complete continuum of cancer research and cancer care needs a thorough overhaul, with more emphasis on prevention and early detection, and a greater focus on the development of innovative treatments that are also scrutinised for effectiveness and quality-of-life aspects. Therefore, under-resourced research areas, such as primary prevention, early diagnosis/secondary prevention (Song et al., ; Wild et al., ) and outcomes research (Cavers et al., ), should be given more emphasis, whereas basic, preclinical and clinical cancer research requires more innovation and effective collaboration to develop more effective treatments at an affordable cost. Innovative collaborative research in this translational trajectory requires the participation of well-resourced and well-organised institutions that are committed to high scientific and ethical standards. Offering focused funding to distinct segments of this research continuum concomitant with incentives to aspire to high-quality standards is the most effective route to achieve these goals. Therefore, a rigorous quality assessment system for institutions operating in this research continuum is a high priority.

摘要

为了在未来几十年为数以百万计的癌症患者提供高质量的癌症护理,癌症研究和癌症护理的整个链条都需要彻底改革,更加注重预防和早期发现,并更加重视创新治疗方法的开发,同时也要对这些治疗方法的有效性和生活质量方面进行严格审查。因此,应更加重视资源不足的研究领域,如初级预防、早期诊断/二级预防(Song 等人,;Wild 等人,)和结果研究(Cavers 等人,),而基础、临床前和临床癌症研究需要更多的创新和有效的合作,以开发更具成本效益的更有效的治疗方法。在这一转化轨迹中的创新协作研究需要有资源丰富且组织良好的机构参与,并致力于高标准的科学和伦理准则。为这一研究连续体的不同部分提供集中的资金,并辅以激励措施以达到高质量标准,是实现这些目标的最有效途径。因此,建立一个严格的质量评估体系来对在这一研究连续体中运作的机构进行评估是当务之急。

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