Curr Med Res Opin. 1988;11(3):149-58. doi: 10.1185/03007998809111134.
A prospective, multi-centre study was carried out in 572 patients undergoing colorectal surgery to investigate the effectiveness of a standardized antibiotic regimen as prophylaxis against post-operative infectious problems. Surgical departments used a single intravenous dose of 400 mg doxycycline plus 1600 mg tinidazole given 1-hour pre-operatively or at induction of anaesthesia. Patients were evaluated clinically 3, 7 and 15 days after surgery. Analysis of the results showed that 18 (3.1%) developed surgical infectious complications. Only 3 (0.5%) of the 21 patients who died during the hospital stay or observation period did so because of septic complications. No serious side-effects were seen. Overall compliance rate with the regimen was 96.9%. There were no signs of declining antibiotic efficacy in hospitals which had been using this regimen for up to 10 years.
一项前瞻性多中心研究在572例接受结直肠手术的患者中开展，以调查标准化抗生素方案预防术后感染问题的有效性。外科科室在术前1小时或麻醉诱导时静脉注射一剂400毫克多西环素加1600毫克替硝唑。术后3天、7天和15天对患者进行临床评估。结果分析显示，18例（3.1%）出现手术感染并发症。在住院期间或观察期内死亡的21例患者中，只有3例（0.5%）死于败血症并发症。未观察到严重副作用。该方案的总体依从率为96.9%。在使用该方案长达10年的医院中，未出现抗生素疗效下降的迹象。
