Curr Med Res Opin. 1988;11(3):171-8. doi: 10.1185/03007998809111136.
The influence of some pre-operative factors on infectious complications after elective abdominal surgery was investigated in a prospective multi-centre study of 1537 patients in surgical departments regularly using a standardized prophylactic antibiotic regimen. A total of 1101 patients received 1600 mg tinidazole plus 400 mg doxycycline intravenously 1-hour pre-operatively. Analysis of the results showed that increasing age, malignancy, risk factors noted by the surgeon before the surgical procedure, and discrepancies between assumed disease and peri-operative findings were associated with significantly more post-operative complications, but not more infectious complications related to peri-operative contamination. Pre-operative hospital stay did not influence the infection rate provided that prophylaxis was given.
在一项针对1537例患者的前瞻性多中心研究中，对定期使用标准化预防性抗生素方案的外科科室中一些术前因素对择期腹部手术后感染并发症的影响进行了调查。共有1101例患者在术前1小时静脉注射1600毫克替硝唑加400毫克多西环素。结果分析表明，年龄增长、恶性肿瘤、外科医生在手术前注意到的危险因素以及假定疾病与围手术期发现之间的差异与术后并发症显著增多有关，但与围手术期污染相关的感染并发症并无更多关联。如果进行了预防，术前住院时间并不影响感染率。
