Curr Med Res Opin. 1988;11(3):179-95. doi: 10.1185/03007998809111137.
A prospective multi-centre study was carried out on 1537 patients to investigate the influence of some peri-operative factors on the infectious complications after elective abdominal surgery in surgical departments where a standardized prophylactic antibiotic regimen is used regularly. The antibiotic regimen consisted of 1600 mg tinidazole and 400 mg doxycycline given intravenously 1-hour preoperatively. The results showed that total gastrectomy seemed to give higher infection rates than other gastroduodenal procedures. Low anterior and abdomino-perineal rectal resections were followed by more infectious complications than colonic resections, but this difference was significant only due to the perineal wound infections and failures of the low anterior anastomosis. Prolonged operation time was followed by increased number of infectious complications only when prophylaxis was not given. Blood transfusions led to a highly significant increase in infectious complications. Peri-operative surgical complications, splenectomy and stoma formation did not influence post-operative infectious complications.
对1537例患者进行了一项前瞻性多中心研究，以调查在常规使用标准化预防性抗生素方案的外科科室中，一些围手术期因素对择期腹部手术后感染并发症的影响。抗生素方案为术前1小时静脉注射1600mg替硝唑和400mg强力霉素。结果显示，全胃切除术的感染率似乎高于其他胃十二指肠手术。低位前切除术和腹会阴直肠切除术的感染并发症比结肠切除术更多，但这种差异仅因会阴部伤口感染和低位前吻合口失败而显著。仅在未进行预防时，手术时间延长会导致感染并发症数量增加。输血导致感染并发症显著增加。围手术期手术并发症、脾切除术和造口形成对术后感染并发症没有影响。
