Curr Med Res Opin. 1988;11(3):159-70. doi: 10.1185/03007998809111135.
The incidence of post-operative infectious complications after high-risk biliary and gastroduodenal and all cases of small bowel surgery was investigated in 965 patients included in a prospective multi-centre study. Selected types of operation where antibiotic prophylaxis was considered beneficial were defined and patients in these categories were to receive a standardized prophylactic regimen of 400 mg doxycycline plus 1600 mg tinidazole intravenously 1-hour pre-operatively or at induction of anaesthesia. Of the 965 patients, 408 did not receive prophylaxis, 547 received the standard regimen and 10 were given a different prophylaxis. The overall compliance rate with the protocol was 89%. Analysis of the results of clinical evaluation of the patients 3, 7 and 15 days after surgery showed that only 21 (2.1%) of the 965 patients had developed surgical infectious complications. Two (0.2%) patients died of septic complications. No serious side-effects of the prophylactic regimen were recorded.
一项前瞻性多中心研究纳入了965例患者，调查了高危胆道、胃十二指肠手术以及所有小肠手术术后感染性并发症的发生率。确定了认为抗生素预防有益的特定手术类型，这些类别的患者在术前1小时或麻醉诱导时静脉接受400mg强力霉素加1600mg替硝唑的标准化预防方案。在965例患者中，408例未接受预防，547例接受了标准方案，10例接受了不同的预防措施。方案的总体依从率为89%。对患者术后3天、7天和15天的临床评估结果分析显示，965例患者中只有21例（2.1%）发生了手术感染并发症。2例（0.2%）患者死于败血症并发症。未记录到预防方案的严重副作用。
