Curr Med Res Opin. 1988;11(3):196-204. doi: 10.1185/03007998809111138.
Serious post-operative infectious complications requiring intensive care treatment were seen regularly in patients undergoing major abdominal surgery before peri-operative antimicrobial prophylaxis was introduced. A prospective multicentre study was carried out to study intensive care requirements in patients undergoing elective surgery of the alimentary tract in hospitals using a standardized antimicrobial prophylaxis regimen of a single intravenous dose of 400 mg doxycycline plus 1600 mg tinidazole 1-hour pre-operatively or at induction of anaesthesia. Only 56 (3.6%) out of the 1537 patients included in the study were treated in an intensive care unit for more than 1 day. Post-operative infectious complications related to peri-operative endogenous contamination were the reason for intensive care treatment in only 4 (0.26%) patients. It is concluded that such infectious complications are no longer the major reason for intensive care treatment after elective gastro-intestinal surgery and the substantial reduction in their frequency has been due to the use of 'short-term barrier' antimicrobial prophylaxis.
在引入围手术期抗菌药物预防措施之前，接受大型腹部手术的患者经常出现需要重症监护治疗的严重术后感染并发症。开展了一项前瞻性多中心研究，以研究在医院接受择期消化道手术的患者的重症监护需求，这些医院采用标准化的抗菌药物预防方案，即术前1小时或麻醉诱导时静脉单次注射400mg多西环素加1600mg替硝唑。在纳入研究的1537例患者中，只有56例（3.6%）在重症监护病房接受了超过1天的治疗。仅4例（0.26%）患者因围手术期内源性污染相关的术后感染并发症而接受重症监护治疗。得出的结论是，此类感染并发症不再是择期胃肠手术后重症监护治疗的主要原因，其发生率的大幅降低归因于使用了“短期屏障”抗菌药物预防措施。
