来自北极真菌 sp. SCSIO 40433 的柱孢菌素。
Cylindromicin from Arctic-Derived Fungus sp. SCSIO 40433.
机构信息
Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China.
South China Sea Institute of Oceanology, University of Chinese Academy of Sciences, Beijing 100049, China.
出版信息
Molecules. 2021 Feb 18;26(4):1080. doi: 10.3390/molecules26041080.
The fungus strain SCSIO 40433 was isolated from an Arctic-derived glacier sediment sample and characterized as . A new compound, cylindromicin (), and seven known secondary metabolites (-) were isolated from this strain. The chemical structures of these compounds were elucidated by comprehensive spectroscopic analyses. Cylindromicin () featured a 3,4-dihydro-2-pyran skeleton. The absolute configuration of compound was assigned via interpretation of key Nuclear Overhauser Effect Spectroscopy (NOESY) correlations and Electronic Circular Dichroism (ECD) calculation. Cylindromicin () exhibited significant tyrosinase inhibition activity. This study highlights Polar fungi as a potential resource for new bioactive natural products.
从北极冰川沉积物样本中分离出的真菌菌株 SCSIO 40433，并对其进行了鉴定。从该菌株中分离得到了一个新化合物（）和七个已知的次级代谢产物（-）。通过全面的光谱分析阐明了这些化合物的化学结构。（）具有 3,4-二氢-2-吡喃骨架。通过关键的核Overhauser 效应光谱（NOESY）相关和电子圆二色性（ECD）计算的解释，确定了化合物的绝对构型。（）对酪氨酸酶具有显著的抑制活性。本研究强调了极地真菌是新型生物活性天然产物的潜在资源。
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