Miller D J, Williams A E, Le Bouvier G L, Dwyer J M, Grant J, Klatskin G
Gastroenterology. 1978 Jun;74(6):1208-13.
Twenty-four HBsAg-positive (HBsAg+) hemodialysis patients were prospectively studied to assess (1) the prognostic value of HBeAg and its HBe1Ag and HBe2Ag components and (2) whether a difference in cellular immune status between HBeAg+ and HBeAg-negative (HBeAg-) patients could be defined. Sixteen patients were HBeAg+ and 8 were HBeAg- initially. After a mean follow-up period of 23.7 months, it was concluded that the initial presence of HBeAg correlated with the persistence of HBsAg because 15 of the 16 HBeAg+ patients were still HBsAg+ at death or last follow-up, whereas 7 of the 8 HBeAg- patients had become HBsAg- at a mean period of 3.8 months. HBe1Ag was consistently present in 15 of the 16 patients when HBeAg was detectable, whereas HBe2Ag fluctuated widely in individual patients over time. No difference in cellular immune status between HBeAg+ and HBeAg- patients could be defined; although both HBeAg+ and HBeAg- patients had a similar decrease in peripheral blood T cells and poor responsiveness to purified HBsAg, both groups of patients had stimulation indices to nonspecific mitogens within the normal range.
对24例乙肝表面抗原阳性（HBsAg+）的血液透析患者进行了前瞻性研究，以评估（1）HBeAg及其HBe1Ag和HBe2Ag成分的预后价值，以及（2）HBeAg阳性和HBeAg阴性（HBeAg-）患者之间的细胞免疫状态是否存在差异。最初，16例患者为HBeAg+，8例为HBeAg-。平均随访23.7个月后得出结论，HBeAg的初始存在与HBsAg的持续存在相关，因为16例HBeAg+患者中有15例在死亡或最后一次随访时仍为HBsAg+，而8例HBeAg-患者中有7例在平均3.8个月时已变为HBsAg-。当可检测到HBeAg时，16例患者中有15例持续存在HBe1Ag，而HBe2Ag在个体患者中随时间波动很大。无法确定HBeAg+和HBeAg-患者之间的细胞免疫状态存在差异；尽管HBeAg+和HBeAg-患者的外周血T细胞均有类似程度的减少，且对纯化的HBsAg反应性较差，但两组患者对非特异性有丝分裂原的刺激指数均在正常范围内。
