Department of Chemistry, University of Manitoba, Winnipeg, Manitoba, Canada
J Bacteriol. 2019 Mar 13;201(7). doi: 10.1128/JB.00697-18. Print 2019 Apr 1.
Lag is a temporary period of nonreplication seen in bacteria that are introduced to new media. Despite latency being described by Müller in 1895, only recently have we gained insights into the cellular processes characterizing lag phase. This review covers literature to date on the transcriptomic, proteomic, metabolomic, physiological, biochemical, and evolutionary features of prokaryotic lag. Though lag is commonly described as a preparative phase that allows bacteria to harvest nutrients and adapt to new environments, the implications of recent studies indicate that a refinement of this view is well deserved. As shown, lag is a dynamic, organized, adaptive, and evolvable process that protects bacteria from threats, promotes reproductive fitness, and is broadly relevant to the study of bacterial evolution, host-pathogen interactions, antibiotic tolerance, environmental biology, molecular microbiology, and food safety.
滞后是指细菌在进入新培养基时出现的一段暂时的非复制期。尽管 Müller 在 1895 年就已经描述了潜伏现象，但直到最近，我们才对描述滞后期的细胞过程有了更深入的了解。这篇综述涵盖了迄今为止关于原核生物滞后的转录组学、蛋白质组学、代谢组学、生理学、生物化学和进化特征的文献。尽管滞后通常被描述为一个准备阶段，使细菌能够收获营养物质并适应新的环境，但最近的研究表明，对这一观点的修正也是理所当然的。如前所述，滞后是一个动态的、有组织的、适应性的和可进化的过程，它可以保护细菌免受威胁，促进生殖适应性，并且与细菌进化、宿主-病原体相互作用、抗生素耐受性、环境生物学、分子微生物学和食品安全的研究广泛相关。
