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林奈提取物水提物对大鼠乙醇诱导胃溃疡的抗氧化和抗炎作用。

Antioxidative and Anti-Inflammatory Effects of Water Extract of Linn. against Ethanol-Induced Gastric Ulcer in Rats.

作者信息

Wu Xue, Huang Qionghui, Xu Nan, Cai Jian, Luo Dandan, Zhang Qian, Su Ziren, Gao Changjun, Liu Yuhong

机构信息

Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.

Guangdong Provincial Key Laboratory of Silviculture, Protection and Utilization, Guangzhou 510520, China.

出版信息

Evid Based Complement Alternat Med. 2018 Dec 12;2018:3585394. doi: 10.1155/2018/3585394. eCollection 2018.

DOI:10.1155/2018/3585394
PMID:30643529
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6311278/
Abstract

Linn., a medicinal pteridophyte growing in mangrove forests and coastal regions of tropical and subtropical areas worldwide, has been proved to possess various biological effects. However, the protective effect of Linn. against gastric ulcer still remains unidentified. Therefore, the gastroprotective effect of the water extract of Linn. (WEAC) was investigated in ethanol-induced gastric injury model. According to our results, pretreatment with WEAC (100, 200, and 400 mg/kg) could dramatically decrease the ulcer areas and ameliorate the pathological damage induced by alcohol in rat's gastric tissues. In addition, WEAC administration prevented the stomach from oxidative damage via markedly increasing the levels of glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and decreasing the malondialdehyde (MDA). Besides, WEAC pretreatment alleviated inflammatory infiltration by reducing the secretion of proinflammatory cytokines including tumor necrosis factor- (TNF-), interleukin-1 (IL-1), and interleukin-6 (IL-6) as well as decreasing the protein expressions of phosphorylation of IB and p65. Taken together, WEAC exerted potential therapeutic efficacy for gastric ulceration, and this may be involved in the suppression of oxidative stress and inflammatory response.

摘要

[植物名称未给出]，一种生长在全球热带和亚热带地区红树林和沿海地区的药用蕨类植物，已被证明具有多种生物学效应。然而，[植物名称未给出]对胃溃疡的保护作用仍不明确。因此，在乙醇诱导的胃损伤模型中研究了[植物名称未给出]水提取物（WEAC）的胃保护作用。根据我们的结果，用WEAC（100、200和400mg/kg）预处理可显著减少溃疡面积，并改善大鼠胃组织中酒精诱导的病理损伤。此外，给予WEAC可通过显著提高谷胱甘肽（GSH）、超氧化物歧化酶（SOD）、过氧化氢酶（CAT）水平并降低丙二醛（MDA）来防止胃的氧化损伤。此外，WEAC预处理通过减少包括肿瘤坏死因子-α（TNF-α）、白细胞介素-1（IL-1）和白细胞介素-6（IL-6）在内的促炎细胞因子的分泌以及降低IκB和p65磷酸化的蛋白表达来减轻炎症浸润。综上所述，WEAC对胃溃疡具有潜在的治疗效果，这可能与抑制氧化应激和炎症反应有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c74/6311278/7f7d5501db2a/ECAM2018-3585394.008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c74/6311278/7f7d5501db2a/ECAM2018-3585394.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c74/6311278/482c1b3975bf/ECAM2018-3585394.001.jpg
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