Mohd Rafie Ahmad Zulkifli, Syahir Amir, Wan Ahmad Wan Amir Nizam, Mustafa Mohd Zulkifli, Mariatulqabtiah Abdul Razak
Department of Cell and Molecular Biology, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.
Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.
Evid Based Complement Alternat Med. 2018 Nov 21;2018:6371582. doi: 10.1155/2018/6371582. eCollection 2018.
is a common stingless bee species found in Southeast Asia. Studies on the health benefits of its honey are limited in comparison with other stingless bee species. This study examines the antiobesity benefits found in stingless bee honey (SBH) from . The parameters used to measure the benefits were weight change, morphological structures, and biochemical characteristics. The research was conducted by using rats that were given a high-fat diet (HFD). In total 48 male Sprague Dawley (SD) rats were given a formulated HFD to increase the levels of obesity, the HFD was administered with a value of 0.68 g/cm. The duration of the treatment was six weeks, and the results show that the induction obesity using the HFD was successful. Following this, the rats were then treated with SBH (at dosages of 1000 mg/kg, 750 mg/kg or 500 mg/kg), with orlistat or with a placebo. Compared with typical obesity treatment methods, the one that used the three dosages of SBH showed a higher reduction in body mass index (BMI), percentage of body weight gain, adiposity index, and relative organ weight (ROW). The levels of liver enzymes (ALT, AST, and ALP) were also significantly lower in SBH-treated groups. The levels of triglycerides and LDL-cholesterol were significantly lower, while the level of HDL-cholesterol was significantly higher in comparison with the control obese group. In terms of morphological structures, the number of adipocyte cells was reduced, and the hepatocytes found in the liver were less prone to rupturing when treated with SBH. In conclusion, the administration of SBH led to an improvement in indicators associated with obesity reduction. SBH also possesses a hepatoprotective potential which can reduce the health risks related to obesity.
是一种在东南亚常见的无刺蜂物种。与其他无刺蜂物种相比，对其蜂蜜健康益处的研究有限。本研究调查了来自[具体来源未提及]的无刺蜂蜂蜜（SBH）的抗肥胖益处。用于衡量这些益处的参数包括体重变化、形态结构和生化特征。该研究使用喂食高脂饮食（HFD）的大鼠进行。总共48只雄性斯普拉格 - 道利（SD）大鼠被给予特制的HFD以增加肥胖水平，HFD的摄入量为0.68克/厘米。治疗持续六周，结果表明使用HFD诱导肥胖成功。在此之后，大鼠分别用SBH（剂量为1000毫克/千克、750毫克/千克或500毫克/千克）、奥利司他或安慰剂进行治疗。与典型的肥胖治疗方法相比，使用三种剂量SBH的方法在体重指数（BMI）、体重增加百分比、肥胖指数和相对器官重量（ROW）方面的降低幅度更大。在SBH治疗组中，肝酶（ALT、AST和ALP）水平也显著更低。与对照肥胖组相比，甘油三酯和低密度脂蛋白胆固醇水平显著更低，而高密度脂蛋白胆固醇水平显著更高。在形态结构方面，脂肪细胞数量减少，用SBH治疗时肝脏中的肝细胞更不易破裂。总之，给予SBH导致与肥胖减轻相关指标的改善。SBH还具有肝脏保护潜力，可降低与肥胖相关的健康风险。
