Ptaszyńska-Sarosiek Iwona, Dunaj Justyna, Zajkowska Agata, Niemcunowicz-Janica Anna, Król Monika, Pancewicz Sławomir, Zajkowska Joanna
Department of Forensic Medicine, Medical University of Bialystok, Białystok, Poland.
Department of Infectious Diseases and Neuroinfections, Medical University of Bialystok, Białystok, Poland.
PeerJ. 2019 Jan 9;6:e6095. doi: 10.7717/peerj.6095. eCollection 2019.
Among over 100 types of viruses, eight can infect humans: herpes simplex viruses (HSV-1, HSV-2), varicella zoster virus (VZV), cytomegalovirus (CMV), Epstein-Barr virus (EBV), and human herpesviruses 6, 7, and 8 (HHV-6, HHV-7, HHV-8). After initial infection, the viruses remain latent for the lifetime of the host. The aim of this study was to determine the distribution of six different herpesviruses: HSV-1, HSV-2, VZV, EBV, CMV, and HHV-6 in trigeminal and facial nerve ganglia among a random group of Polish population.
The studied group consisted of 47 individuals (40 male, seven female); mean age of 47.4 ± 16.5 years) who died of independent causes (suicide, traffic accident, and poisoning, among others). Bilateral trigeminal and facial nerve ganglia of each cadaver were collected during the autopsy. Herpesviruses were detected using multiplex polymerase chain reaction technique.
Herpesviruses were found in trigeminal and/or facial ganglia in 30/47 (63.8%) of cadavers. HHV-6 was the most prevalent of the herpesviruses and was found in nearly half of cadavers ( = 22; 46.8%), followed by HSV-1 ( = 7; 14.9%), VZV ( = 4; 8.5%), EBV ( = 4; 8.5%), HSV-2 ( = 2; 4.3%), and CMV ( = 1; 2.1%). Facial nerve ganglia ( = 23; 48.9%) were more often infected than trigeminal ganglia ( = 13; 27.7%).
The results of this study have revealed a common presence of the herpesviruses in trigeminal and facial nerve ganglia among a random group of Polish population. Furthermore, the data also demonstrate simultaneous infection of the ganglia with different herpesviruses. This study has contributed to the knowledge of prevalence and localization of herpesviruses in different structures of the nervous system.
在100多种病毒中，有8种可感染人类：单纯疱疹病毒（HSV-1、HSV-2）、水痘带状疱疹病毒（VZV）、巨细胞病毒（CMV）、爱泼斯坦-巴尔病毒（EBV）以及人类疱疹病毒6型、7型和8型（HHV-6、HHV-7、HHV-8）。初次感染后，这些病毒会在宿主的一生中保持潜伏状态。本研究的目的是确定六种不同疱疹病毒：HSV-1、HSV-2、VZV、EBV、CMV和HHV-6在波兰随机人群三叉神经节和面神经节中的分布情况。
研究组由47名个体组成（40名男性，7名女性）；平均年龄为47.4±16.5岁，他们死于独立原因（如自杀、交通事故和中毒等）。在尸检过程中收集每个尸体的双侧三叉神经节和面神经节。使用多重聚合酶链反应技术检测疱疹病毒。
在30/47（63.8%）的尸体的三叉神经节和/或面神经节中发现了疱疹病毒。HHV-6是最常见的疱疹病毒，在近一半的尸体中发现（n = 22；46.8%），其次是HSV-1（n = 7；14.9%）、VZV（n = 4；8.5%）、EBV（n = 4；8.5%）、HSV-2（n = 2；4.3%）和CMV（n = 1；2.1%）。面神经节（n = 23；48.9%）比三叉神经节（n = 13；27.7%）更常受到感染。
本研究结果揭示了疱疹病毒在波兰随机人群的三叉神经节和面神经节中普遍存在。此外，数据还表明神经节同时受到不同疱疹病毒的感染。本研究有助于了解疱疹病毒在神经系统不同结构中的患病率和定位情况。
