Ramaswamy Reddy Shwetha Hulimavu, Reddy Roopa, Babu N Chaitanya, Ashok G N
Department of Oral Pathology, MMNG Halgekar Institute of Dental Science, Belagavi, Karnataka, India.
Center for Incubation, Innovation, Research and Consultancy, Jyothy Institute of Technology, Bengaluru, Karnataka, India.
J Oral Maxillofac Pathol. 2018 Sep-Dec;22(3):367-374. doi: 10.4103/jomfp.JOMFP_93_18.
Regenerative medicine encompasses new emerging branch of medical sciences that involves the functional restoration of tissues or organs caused by severe injuries or chronic diseases. Currently, there are two contending technologies that can repair and restore the damaged tissues, namely platelet-rich plasma (PRP)- and stem cell (SC)-based therapies. PRP is a component of blood that contains platelet concentrations above the normal level and includes platelet-related growth factors and plasma-derived fibrinogen. Platelets are the frontline healing response to injuries as they release growth factors for tissue repair. SCs, on the other hand, are the unspecialized, undifferentiated, immature cells that based on specific stimuli can divide and differentiate into specific type of cells and tissues. Differentiated SCs can divide and replace the worn out or damaged tissues to become tissue- or organ-specific cells with specialized functions. Despite these differences, both approaches rely on rejuvenating the damaged tissue. This review is focused on delineating the preparation procedures, similarities and disparities and advantages and disadvantages of PRP- and SC-based therapies.
再生医学涵盖了医学科学中一个新兴的分支领域，它涉及由严重损伤或慢性疾病导致的组织或器官功能恢复。目前，有两种相互竞争的技术可以修复和恢复受损组织，即基于富血小板血浆（PRP）和干细胞（SC）的疗法。PRP是血液的一种成分，其血小板浓度高于正常水平，包含与血小板相关的生长因子和血浆来源的纤维蛋白原。血小板是损伤愈合的一线反应，因为它们会释放促进组织修复的生长因子。另一方面，干细胞是未特化、未分化、不成熟的细胞，基于特定刺激可以分裂并分化为特定类型的细胞和组织。分化后的干细胞可以分裂并替代磨损或受损的组织，成为具有特定功能的组织或器官特异性细胞。尽管存在这些差异，但两种方法都依赖于使受损组织恢复活力。本综述聚焦于阐述基于PRP和干细胞疗法的制备程序、异同点以及优缺点。
