聚合物包覆的超顺磁性氧化铁纳米颗粒作为磁共振成像的T造影剂及其在肝脏中的摄取。

Polymer-coated superparamagnetic iron oxide nanoparticles as T contrast agent for MRI and their uptake in liver.

作者信息

Ali Lamiaa Ma, Marzola Pasquina, Nicolato Elena, Fiorini Silvia, Heras Guillamón Marcelo de Las, Piñol Rafael, Gabilondo Lierni, Millán Angel, Palacio Fernando

机构信息

Instituto de Ciencia de Materiales de Aragón, CSIC - Universidad de Zaragoza; & Departamento de Física de la Materia Condensada, Facultad de Ciencias, 50009 Zaragoza, Spain.

Department of Computer Science, Verona University, Verona, Italy.

出版信息

Future Sci OA. 2017 Sep 18;5(1):FSO235. doi: 10.4155/fsoa-2017-0054. eCollection 2019 Jan.

AIM

To study the efficiency of multifunctional polymer-based superparamagnetic iron oxide nanoparticles (bioferrofluids) as a T magnetic resonance contrast agent and their uptake and toxicity in liver.

MATERIALS & METHODS: Mice were intravenously injected with bioferrofluids and Endorem. The magnetic resonance efficiency, uptake and toxicity were investigated by means of magnetic resonance imaging (MRI) and histological techniques.

RESULTS

Bioferrofluids are a good T contrast agent with a higher r/r ratio than Endorem. Bioferrofluids have a shorter blood circulation time and persist in liver for longer time period compared with Endorem. Both bioferrofluids and Endorem do not generate any noticeable histological lesions in liver over a period of 60 days post-injection.