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聚合物包覆的超顺磁性氧化铁纳米颗粒作为磁共振成像的T造影剂及其在肝脏中的摄取。

Polymer-coated superparamagnetic iron oxide nanoparticles as T contrast agent for MRI and their uptake in liver.

作者信息

Ali Lamiaa Ma, Marzola Pasquina, Nicolato Elena, Fiorini Silvia, Heras Guillamón Marcelo de Las, Piñol Rafael, Gabilondo Lierni, Millán Angel, Palacio Fernando

机构信息

Instituto de Ciencia de Materiales de Aragón, CSIC - Universidad de Zaragoza; & Departamento de Física de la Materia Condensada, Facultad de Ciencias, 50009 Zaragoza, Spain.

Department of Computer Science, Verona University, Verona, Italy.

出版信息

Future Sci OA. 2017 Sep 18;5(1):FSO235. doi: 10.4155/fsoa-2017-0054. eCollection 2019 Jan.

DOI:10.4155/fsoa-2017-0054
PMID:30652014
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6331706/
Abstract

AIM

To study the efficiency of multifunctional polymer-based superparamagnetic iron oxide nanoparticles (bioferrofluids) as a T magnetic resonance contrast agent and their uptake and toxicity in liver.

MATERIALS & METHODS: Mice were intravenously injected with bioferrofluids and Endorem. The magnetic resonance efficiency, uptake and toxicity were investigated by means of magnetic resonance imaging (MRI) and histological techniques.

RESULTS

Bioferrofluids are a good T contrast agent with a higher r/r ratio than Endorem. Bioferrofluids have a shorter blood circulation time and persist in liver for longer time period compared with Endorem. Both bioferrofluids and Endorem do not generate any noticeable histological lesions in liver over a period of 60 days post-injection.

CONCLUSION

Our bioferrofluids are powerful diagnostic tool without any observed toxicity over a period of 60 days post-injection.

摘要

目的

研究基于多功能聚合物的超顺磁性氧化铁纳米颗粒（生物铁流体）作为T磁共振造影剂的效能及其在肝脏中的摄取和毒性。

材料与方法

给小鼠静脉注射生物铁流体和恩多雷姆。通过磁共振成像（MRI）和组织学技术研究磁共振效能、摄取和毒性。

结果

生物铁流体是一种良好的T造影剂，其r/r比高于恩多雷姆。与恩多雷姆相比，生物铁流体的血液循环时间较短，在肝脏中持续的时间较长。在注射后60天内，生物铁流体和恩多雷姆在肝脏中均未产生任何明显的组织学损伤。

结论

我们的生物铁流体是一种强大的诊断工具，在注射后60天内未观察到任何毒性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fb3/6331706/6dac84291f30/fsoa-05-235-g9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fb3/6331706/3f6dca02bf8a/fsoa-05-235-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fb3/6331706/3eb0db1da789/fsoa-05-235-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fb3/6331706/451df736a76b/fsoa-05-235-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fb3/6331706/fc9ceb1f5406/fsoa-05-235-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fb3/6331706/10a40dbd84f4/fsoa-05-235-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fb3/6331706/443945f491b6/fsoa-05-235-g6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fb3/6331706/8e6b5ec6a880/fsoa-05-235-g7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fb3/6331706/27a30775a355/fsoa-05-235-g8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fb3/6331706/6dac84291f30/fsoa-05-235-g9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fb3/6331706/3f6dca02bf8a/fsoa-05-235-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fb3/6331706/3eb0db1da789/fsoa-05-235-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fb3/6331706/451df736a76b/fsoa-05-235-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fb3/6331706/fc9ceb1f5406/fsoa-05-235-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fb3/6331706/10a40dbd84f4/fsoa-05-235-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fb3/6331706/443945f491b6/fsoa-05-235-g6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fb3/6331706/8e6b5ec6a880/fsoa-05-235-g7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fb3/6331706/27a30775a355/fsoa-05-235-g8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fb3/6331706/6dac84291f30/fsoa-05-235-g9.jpg

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