Laboratory of Tumor and Development Biology, Groupe Interdisciplinaire de Génoprotéomique Appliqué-Cancer (GIGA-Cancer), University of Liège, Liège 4000, Belgium.
Int J Mol Sci. 2019 Jan 16;20(2):354. doi: 10.3390/ijms20020354.
MT4-MMP (or MMP17) belongs to the Membrane-Type Matrix Metalloproteinase (MT-MMP) family. This family of proteases contributes to extracellular matrix remodeling during several physiological processes, including embryogenesis, organogenesis, tissue regeneration, angiogenesis, wound healing, and inflammation. MT4-MMP (MMP17) presents unique characteristics compared to other members of the family in terms of sequence homology, substrate specificity, and internalization mode, suggesting distinct physiological and pathological functions. While the physiological functions of MT4-MMP are poorly understood, it has been involved in different pathological processes such as arthritis, cardiovascular disease, and cancer progression. The transcript has been detected in a large diversity of cancers. The contribution of MT4-MMP to tumor development has been further investigated in gastric cancer, colon cancer, head and neck cancer, and more deeply in breast cancer. Given its contribution to different pathologies, particularly cancers, MT4-MMP represents an interesting therapeutic target. In this review, we examine its biological and structural properties, and we propose an overview of its physiological and pathological functions.
MT4-MMP（或 MMP17）属于膜型基质金属蛋白酶（MT-MMP）家族。该蛋白酶家族在几种生理过程中有助于细胞外基质的重塑，包括胚胎发生、器官发生、组织再生、血管生成、伤口愈合和炎症。与家族中的其他成员相比，MT4-MMP（MMP17）在序列同源性、底物特异性和内化模式方面具有独特的特征，提示其具有不同的生理和病理功能。尽管 MT4-MMP 的生理功能尚未完全了解，但它已参与关节炎、心血管疾病和癌症进展等不同的病理过程。在大量不同的癌症中都检测到了该转录物。MT4-MMP 对胃癌、结肠癌、头颈部癌症等癌症发展的贡献已进一步研究，并在乳腺癌中进行了更深入的研究。鉴于其对不同病理，特别是癌症的贡献，MT4-MMP 代表了一个有趣的治疗靶点。在这篇综述中，我们研究了它的生物学和结构特性，并提出了它的生理和病理功能概述。
