Almatroudi Ahmad, Alsahli Mohammed A, Alrumaihi Faris, Allemailem Khaled S, Rahmani Arshad H
Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraidah, Saudi Arabia.
Curr Pharm Biotechnol. 2019;20(1):5-16. doi: 10.2174/1389201020666190119142331.
Numerous studies have been performed in understanding the development of cancer. Though, the mechanism of action of genes in the development of cancer remains to be explained. The current mode of treatment of cancer shows adverse effects on normal cells and also alter the cell signalling pathways. However, ginger and its active compound have fascinated research based on animal model and laboratories during the past decade due to its potentiality in killing cancer cells. Ginger is a mixture of various compounds including gingerol, paradol, zingiberene and shogaol and such compounds are the main players in diseases management. Most of the health-promoting effects of ginger and its active compound can be attributed due to its antioxidant and anti-tumour activity. Besides, the active compound of ginger has proven its role in cancer management through its modulatory effect on tumour suppressor genes, cell cycle, apoptosis, transcription factors, angiogenesis and growth factor. In this review, the role of ginger and its active compound in the inhibition of cancer growth through modulating cell signalling pathways will be reviewed and discussed.
为了解癌症的发展，人们已经进行了大量研究。然而，基因在癌症发展中的作用机制仍有待解释。目前的癌症治疗方式对正常细胞有不良影响，还会改变细胞信号通路。然而，在过去十年中，生姜及其活性化合物因其杀死癌细胞的潜力，在基于动物模型和实验室的研究中备受关注。生姜是多种化合物的混合物，包括姜辣素、姜二醇、姜烯和姜辣烯酮，这些化合物是疾病管理的主要参与者。生姜及其活性化合物的大多数健康促进作用可归因于其抗氧化和抗肿瘤活性。此外，生姜的活性化合物通过对肿瘤抑制基因、细胞周期、细胞凋亡、转录因子、血管生成和生长因子的调节作用，已证明其在癌症管理中的作用。在本综述中，将对生姜及其活性化合物通过调节细胞信号通路抑制癌症生长的作用进行综述和讨论。
