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低尼古丁含量香烟试验参与者对SPECTRUM研究香烟的可接受性。

Acceptability of SPECTRUM Research Cigarettes among Participants in Trials of Reduced Nicotine Content Cigarettes.

作者信息

Veldheer Susan, Midya Vishal, Lester Courtney, Liao Jason, Yingst Jessica, Hrabovsky Shari, Allen Sophia I, Krebs Nicolle M, Reinhart Lisa, Evins A Eden, Horn Kimberly, Richie John, Muscat Joshua, Foulds Jonathan

机构信息

Penn State Tobacco Center of Regulatory Science (TCORS), Penn State College of Medicine, Department of Public Health Sciences.

Massachusetts General Hospital Department of Psychiatry, Harvard Medical School, Boston.

出版信息

Tob Regul Sci. 2018 Jan;4(1):573-585. doi: 10.18001/TRS.4.1.4.

Abstract

OBJECTIVES

SPECTRUM research cigarettes (SPECTRUMs) are being used in trials evaluating the effects of switching to reduced nicotine content (RNC) cigarettes. Because smokers have a high brand affinity, we evaluated if they were willing to switch and continue smoking normal nicotine content (NNC) SPECTRUMs.

METHODS

We asked smokers (N = 341) to rate their own brand of cigarettes and NNC SPECTRUMs (after 2 weeks of use) using subjective measures including satisfaction, reward, taste, and craving reduction. We measured plasma cotinine, exhaled carbon monoxide (CO), and cigarettes per day (CPD), and recorded reasons for dropping out.

RESULTS

After 2 weeks, 95% of participants chose to continue using SPECTRUMs for an additional 18 weeks. Moreover, 67% said SPECTRUMs were as good as or better than their own brand, and 65% said they would consider purchasing them. Ratings of satisfaction, reward, and craving reduction were 10%-15% lower on SPECTRUMs than on their own brand (p < .01). There were no differences in these ratings between menthol and non-menthol smokers.

CONCLUSIONS

Menthol and non-menthol SPECTRUMs are acceptable to smokers. Lower SPECTRUM ratings were likely due to brand switching and did not hinder study retention.

摘要

目的

光谱研究香烟(SPECTRUMs)正用于评估改用尼古丁含量降低(RNC)香烟效果的试验中。由于吸烟者对品牌的忠诚度较高,我们评估了他们是否愿意改用并继续吸食正常尼古丁含量(NNC)的光谱研究香烟。

方法

我们让吸烟者(N = 341)使用包括满意度、满足感、口感和减少烟瘾等主观指标,对他们自己品牌的香烟和使用两周后的NNC光谱研究香烟进行评分。我们测量了血浆可替宁、呼出一氧化碳(CO)以及每日吸烟量(CPD),并记录退出原因。

结果

两周后,95%的参与者选择继续使用光谱研究香烟另外18周。此外,67%的人表示光谱研究香烟与他们自己的品牌一样好或更好,65%的人表示会考虑购买。光谱研究香烟在满意度、满足感和减少烟瘾方面的评分比他们自己品牌的香烟低10% - 15%(p <.01)。薄荷醇吸烟者和非薄荷醇吸烟者在这些评分上没有差异。

结论

薄荷醇和非薄荷醇光谱研究香烟为吸烟者所接受。光谱研究香烟较低的评分可能是由于品牌转换,且并未妨碍研究的持续进行。

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