N6-甲基腺苷调控病毒复制和 T 细胞动态平衡。
Regulation of Virus Replication and T Cell Homeostasis by N-Methyladenosine.
机构信息
Institute of Virology and AIDS Research, The First Hospital of Jilin University, Changchun, 130021, China.
出版信息
Virol Sin. 2019 Feb;34(1):22-29. doi: 10.1007/s12250-018-0075-5. Epub 2019 Jan 22.
RNA modifications are abundant in eukaryotes, bacteria, and archaea. N-methyladenosine (mA), a type of RNA modification mainly found in messenger RNA (mRNA), has significant effects on the metabolism and function of mRNAs. This modification is governed by three types of proteins, namely methyltransferases as "writers", demethylases as "erasers", and specific mA-binding proteins (YTHDF1-3) as "readers". Further, it is important for the regulation of cell fate and has a critical function in many biological processes including virus replication, stem cell differentiation, and cancer development, and exerts its effect by controlling gene expression. Herein, we summarize recent advances in research on mA in virus replication and T cell regulation, which is a rapidly emerging field that will facilitate the development of antiviral therapies and the study of innate immunity.
RNA 修饰在真核生物、细菌和古菌中普遍存在。N6-甲基腺嘌呤（m6A）是一种主要存在于信使 RNA（mRNA）中的 RNA 修饰，对 mRNA 的代谢和功能有重要影响。这种修饰受三种类型的蛋白质调控，即甲基转移酶作为“书写器”、去甲基酶作为“橡皮擦”和特定的 m6A 结合蛋白（YTHDF1-3）作为“阅读器”。此外，它对于细胞命运的调节很重要，在包括病毒复制、干细胞分化和癌症发展在内的许多生物学过程中具有关键功能，并通过控制基因表达来发挥作用。本文总结了 m6A 在病毒复制和 T 细胞调节方面的研究进展，这是一个迅速发展的领域，将有助于开发抗病毒疗法和研究先天免疫。
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