School of Health, Sports and Bioscience, University of East London, Stratford Campus, Water Lane, LondonE15 4LZ, UK.
Molecules. 2019 Jan 22;24(3):385. doi: 10.3390/molecules24030385.
Bioassay directed isolation of secondary metabolites from the rhizomes of (Fam. Zingiberaceae) led to the isolation of mono-, sesqui-, and di-terpenes. The compounds were characterized as ()-8(17),12-labdadiene-15,16-dial (), zerumbol (), zerumbone (), buddledone A (), furanodienone (), germacrone (), borneol (), and camphor () by analysing one-dimensional (1D) (¹H and C) and two-dimensional (2D) (COSY, HSQC, HMBC, and NOESY) NMR data and mass spectra. Among these terpenes, compounds and revealed potential antibacterial activity (minimum inhibitory concentrations (MIC) values 32⁻128 µg/mL; 0.145⁻0.291 mM)) against a series of clinical isolates of multi-drug resistant (MDR) and Methicillin resistant (MRSA).
生物活性导向分离姜科植物蓬莪术（Fam. Zingiberaceae）根茎中的次生代谢产物，得到了单萜、倍半萜和二萜类化合物。通过分析一维（1D）（¹H 和 C）和二维（2D）（COSY、HSQC、HMBC 和 NOESY）NMR 数据和质谱，这些化合物被鉴定为 ()-8(17),12-labdadiene-15,16-dial ()、莪术醇（）、莪术酮（）、菖蒲二酮 A（）、呋喃二烯酮（）、倍半萜烯（）、龙脑（）和樟脑（）。在这些萜类化合物中，化合物 和 表现出潜在的抗菌活性（最低抑菌浓度（MIC）值为 32⁻128 µg/mL；0.145⁻0.291 mM），对一系列耐多药（MDR）和耐甲氧西林金黄色葡萄球菌（MRSA）的临床分离株有效。
