Zika 病毒的亚洲谱系：在亚洲和美洲的传播与演变。
The Asian Lineage of Zika Virus: Transmission and Evolution in Asia and the Americas.
机构信息
Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Taishan Medical College, Taian, 271000, China.
Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, Sapporo, 001-0020, Japan.
出版信息
Virol Sin. 2019 Feb;34(1):1-8. doi: 10.1007/s12250-018-0078-2. Epub 2019 Jan 25.
Since first isolation in 1947 from the Zika forest in Uganda, Zika virus (ZIKV) has been principally known as a benign agent associated with sporadic human infections in a restricted number of African countries. However, during 2015-2016, an Asian lineage of ZIKV caused an unprecedentedly large outbreak in the Americas and sizeable numbers of exported cases across the globe. In this review, we critically appraise the recent advances in molecular epidemiological studies of ZIKV performed to date, and we highlight the pivotal role played by genomic surveillance in elucidating the origins, dissemination and evolution of the Asian lineage of ZIKV in Asia and in the Americas.
自 1947 年从乌干达的 Zika 森林首次分离出来以来，寨卡病毒（ZIKV）主要被认为是一种良性病原体，与少数非洲国家的散发性人类感染有关。然而，在 2015-2016 年期间，一种亚洲谱系的寨卡病毒在美洲引发了一次空前规模的疫情，并在全球范围内出现了大量的输入病例。在这篇综述中，我们批判性地评估了迄今为止针对寨卡病毒进行的分子流行病学研究的最新进展，并强调了基因组监测在阐明亚洲谱系寨卡病毒在亚洲和美洲的起源、传播和进化方面所发挥的关键作用。
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