Mucalo Michael R
School of Science, University of Waikato, Private Bag 3105, Hamilton 3240, New Zealand.
Materials (Basel). 2019 Jan 28;12(3):405. doi: 10.3390/ma12030405.
Research on calcium phosphate use in the development and clinical application of biomedical materials is a diverse activity and is genuinely interdisciplinary, with much work leading to innovative solutions for improvement of health outcomes. This Special Issue aimed to summarize current advances in this area. The nine papers published cover a wide spectrum of topical areas, such as (1) remineralisation pastes for decalcified teeth, (2) use of statins to enhance bone formation, (3) how dolomitic marble and seashells can be processed into bioceramic materials, (4) relationships between the roughness of calcium phosphate surfaces and surface charge with the effect on human MRC osteogenic differentiation and maturation being investigated, (5) rheological and mechanical properties of a novel injectable bone substitute, (6) improving strength of bone cements by incorporating reinforcing chemically modified fibres, (7) using adipose stem cells to stimulate osteogenesis, osteoinduction, and angiogenesis on calcium phosphates, (8) using glow discharge treatments to remove surface contaminants from biomedical materials to enhance cell attachment and improve bone generation, and (9) a review on how classically brittle hydroxyapatite based scaffolds can be improved by making fibre-hydroxyapatite composites, with detailed analysis of ceramic crack propagation mechanisms and its prevention via fibre incorporation in the hydroxyapatite.
关于磷酸钙在生物医学材料开发和临床应用中的研究是一项多样的活动,并且真正具有跨学科性质,许多工作都带来了改善健康结果的创新解决方案。本期特刊旨在总结该领域的当前进展。发表的九篇论文涵盖了广泛的主题领域,例如:(1)用于脱矿质牙齿的再矿化糊剂;(2)使用他汀类药物增强骨形成;(3)如何将白云石大理石和贝壳加工成生物陶瓷材料;(4)正在研究磷酸钙表面粗糙度和表面电荷之间的关系及其对人MRC成骨细胞分化和成熟的影响;(5)一种新型可注射骨替代物的流变学和力学性能;(6)通过加入增强化学改性纤维提高骨水泥强度;(7)利用脂肪干细胞刺激磷酸钙上的骨生成、骨诱导和血管生成;(8)使用辉光放电处理去除生物医学材料表面污染物以增强细胞附着并改善骨生成;以及(9)一篇关于如何通过制备纤维 - 羟基磷灰石复合材料来改进传统脆性羟基磷灰石基支架的综述,详细分析了陶瓷裂纹扩展机制及其通过在羟基磷灰石中加入纤维来预防的方法。