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在存在终末事件的情况下,对复发事件研究中的边缘特征进行建模。

Modeling marginal features in studies of recurrent events in the presence of a terminal event.

作者信息

Andersen Per Kragh, Angst Jules, Ravn Henrik

机构信息

Section of Biostatistics, University of Copenhagen, Ø. Farimagsgade 5, PB 2099, 1014, Copenhagen K, Denmark.

Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zürich, Zurich, Switzerland.

出版信息

Lifetime Data Anal. 2019 Oct;25(4):681-695. doi: 10.1007/s10985-019-09462-4. Epub 2019 Jan 29.

Abstract

We study models for recurrent events with special emphasis on the situation where a terminal event acts as a competing risk for the recurrent events process and where there may be gaps between periods during which subjects are at risk for the recurrent event. We focus on marginal analysis of the expected number of events and show that an Aalen-Johansen type estimator proposed by Cook and Lawless is applicable in this situation. A motivating example deals with psychiatric hospital admissions where we supplement with analyses of the marginal distribution of time to the competing event and the marginal distribution of the time spent in hospital. Pseudo-observations are used for the latter purpose.

摘要

我们研究复发事件的模型,特别关注这样一种情况:终端事件对复发事件过程构成竞争风险,并且在受试者面临复发事件风险的时间段之间可能存在间隔。我们专注于对事件预期数量的边际分析,并表明库克和劳利斯提出的一种Aalen-Johansen型估计量适用于这种情况。一个具有启发性的例子涉及精神病医院的入院情况,在此我们补充了对竞争事件发生时间的边际分布以及住院时间的边际分布的分析。后一个目的使用了伪观测值。

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