从矿土来源的枝顶孢属中分离得到的具有侧链取代的吲哚二萜生物碱
Prenylated Indole Diterpene Alkaloids from a Mine-Soil-Derived Tolypocladium sp.
机构信息
School of Pharmaceutical Sciences , South-Central University for Nationalities , Wuhan 430074 , People's Republic of China.
Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences , Chongqing University , Chongqing 401331 , People's Republic of China.
出版信息
J Nat Prod. 2019 Feb 22;82(2):221-231. doi: 10.1021/acs.jnatprod.8b00589. Epub 2019 Jan 31.
Ten new prenylated indole diterpene alkaloids, tolypocladin A-J (1-10), including four chlorinated metabolites, have been isolated from a culture of a mine-soil-derived fungus, Tolypocladium sp. XL115. The structures and absolute configurations of 1-10 were determined by spectroscopic analysis, ECD calculations, and comparison with known compounds. Compounds 1 and 8 displayed significant antimicrobial activities. In addition, compound 1 also showed weak cytotoxic activity against all tested human cancer cell lines and suppressed the growth and viability of the patient-derived HCC cells T1224.
从一株采自矿区土壤的真菌 Tolypocladium sp. XL115 的培养物中分离得到了 10 个新的prenylated indole diterpene alkaloids，即 tolypocladin A-J（1-10），包括 4 个氯化代谢物。通过光谱分析、ECD 计算和与已知化合物的比较，确定了 1-10 的结构和绝对构型。化合物 1 和 8 表现出显著的抗菌活性。此外，化合物 1 还对所有测试的人类癌细胞系表现出较弱的细胞毒性活性，并抑制了患者来源的 HCC 细胞 T1224 的生长和活力。
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