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通过24小时尿液收集测量的盐摄入量与维多利亚(巴西)成年人口血压之间的关系。

Relationship between salt consumption measured by 24-h urine collection and blood pressure in the adult population of Vitória (Brazil).

作者信息

Rodrigues S L, Souza Júnior P R, Pimentel E B, Baldo M P, Malta D C, Mill J G, Szwarcwald C L

机构信息

Departamento de Ciências Fisiológicas, Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, Vitória, ES, Brasil.

Centro de Informação Científica e Tecnológica, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brasil.

出版信息

Braz J Med Biol Res. 2015 Aug;48(8):728-35. doi: 10.1590/1414-431X20154455. Epub 2015 Jun 30.

Abstract

High salt intake is related to an increase in blood pressure and development of hypertension. However, currently, there are no national representative data in Brazil using the gold standard method of 24-h urine collection to measure sodium consumption. This study aimed to determine salt intake based on 24-h urine collection in a sample of 272 adults of both genders and to correlate it with blood pressure levels. We used a rigorous protocol to assure an empty bladder prior to initiating urine collection. We excluded subjects with a urine volume <500 mL, collection period outside of an interval of 23-25 h, and subjects with creatinine excretion that was not within the range of 14.4-33.6 mg/kg (men) and 10.8-25.2 mg/kg (women). The mean salt intake was 10.4±4.1 g/day (d), and 94% of the participants (98% of men and 90% of women) ingested more than the recommended level of 5 g/d. We found a positive association between salt and body mass index (BMI) categories, as well as with salt and blood pressure, independent of age and BMI. The difference in systolic blood pressure reached 13 mmHg between subjects consuming less than 6 g/d of salt and those ingesting more than 18 g/d. Subjects with hypertension had a higher estimated salt intake than normotensive subjects (11.4±5.0 vs 9.8±3.6 g/d, P<0.01), regardless of whether they were under treatment. Our data indicate the need for interventions to reduce sodium intake, as well the need for ongoing, appropriate monitoring of salt consumption in the general population.

摘要

高盐摄入与血压升高及高血压的发生有关。然而,目前在巴西尚无使用24小时尿样采集这一黄金标准方法来测量钠摄入量的全国代表性数据。本研究旨在通过对272名成年男女的样本进行24小时尿样采集来确定盐摄入量,并将其与血压水平相关联。我们采用了严格的方案以确保在开始尿液采集前膀胱排空。我们排除了尿量<500 mL、采集时间段不在23 - 25小时区间内以及肌酐排泄量不在14.4 - 33.6 mg/kg(男性)和10.8 - 25.2 mg/kg(女性)范围内的受试者。平均盐摄入量为10.4±4.1克/天(d),94%的参与者(98%的男性和90%的女性)摄入的盐超过了推荐水平5克/天。我们发现盐与体重指数(BMI)类别之间以及盐与血压之间存在正相关,且不受年龄和BMI的影响。盐摄入量低于6克/天的受试者与摄入超过18克/天的受试者之间收缩压差值达13 mmHg。高血压患者的估计盐摄入量高于血压正常的受试者(11.4±5.0 vs 9.8±3.6克/天,P<0.01),无论他们是否正在接受治疗。我们的数据表明需要采取干预措施来减少钠摄入量,同时也需要对普通人群的盐摄入量进行持续、适当的监测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3740/4541693/e19384899bba/1414-431X-bjmbr-48-08-00728-gf001.jpg

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