Rose G, Stamler J
Department of Epidemiology and Population Sciences, London School of Hygiene and Tropical Medicine, UK.
J Hum Hypertens. 1989 Oct;3(5):283-8.
The INTERSALT study used standardised methods to assess the relations of electrolyte intake and blood pressure, taking account of confounding variables, in samples of men and women aged 20-59 drawn from defined populations in 52 centres and 32 countries (10,079 individuals). Sodium excretion was significantly related to blood pressure in individuals. Corrected estimates (probably still too low) indicated, on multiple regression, that a difference of 100 mmol/day in average population sodium intake corresponded to 2.2 mmHg lower systolic pressure. Sodium excretion across centres, with median levels ranging from 0.2 to 242 mmol/24 hour, was related to slope of blood pressure with age, less consistently to median centre pressure. Estimates indicated that a 100 mmol/day lower sodium intake was associated with a 9 mmHg lower rise of systolic pressure between ages 25 and 55. Hypertension was virtually absent in four populations with very low sodium intake, and blood pressure in these samples was not higher at older ages. Potassium intake of individuals was negatively and significantly associated with blood pressure independently of other variables; body mass index and high alcohol intake were strongly positively and independently associated with blood pressure in individuals.
国际食盐与血压关系研究（INTERSALT研究）采用标准化方法，在来自52个中心和32个国家（10,079名个体）特定人群中抽取的20至59岁男性和女性样本中，评估电解质摄入量与血压的关系，并考虑了混杂变量。个体的钠排泄量与血压显著相关。校正后的估计值（可能仍偏低）在多元回归分析中表明，人群平均钠摄入量每天相差100 mmol，收缩压相应降低2.2 mmHg。各中心的钠排泄量（中位数水平为0.2至242 mmol/24小时）与血压随年龄变化的斜率相关，与中心血压中位数的相关性则不太一致。估计表明，钠摄入量每天降低100 mmol，25至55岁之间收缩压的升高幅度会降低9 mmHg。在钠摄入量极低的四个人群中，几乎没有高血压患者，而且这些样本中的血压在年龄较大时也不会更高。个体的钾摄入量与血压呈负相关且具有显著相关性，独立于其他变量；体重指数和高酒精摄入量与个体血压呈强正相关且相互独立。
