Department of Nutrition and Health, Universidade Federal de Viçosa, Av. Purdue, s/n, Campus Universitário, Viçosa, MG 36.570-900, Brazil.
Department of Nutrition and Health, Universidade Federal de Viçosa, Av. Purdue, s/n, Campus Universitário, Viçosa, MG 36.570-900, Brazil.
Food Res Int. 2019 Feb;116:592-599. doi: 10.1016/j.foodres.2018.08.078. Epub 2018 Aug 29.
Chia is a good source of calcium, however it is not been previously reported its bioavailability associated with an inflammatory condition. Thus, the present study evaluated the effect of chia on calcium bioavailability, inflammation, and oxidative stress in Wistar rats fed a high-fat diet or standard diet for 35 days. Chia consumption resulted in lower calcium balance and calcium absorption and retention rates. In addition, the urinary calcium concentration was lower in groups that were fed chia. The bone resistance of animals feed chia was lower than that in rats fed the standard diet receiving calcium carbonate. Animals that were fed chia showed lower total, very low-density lipoprotein, and low-density lipoprotein cholesterol levels than animalsfed calcium carbonate. Animals fed standard diet showed higher superoxide dismutase plasma concentrations than animals in the high fat calcium carbonate group. PPAR-α protein levels were higher in animals fed chia whereas TNF-α and IL-10 were lower in these animals. NFκB mRNA expression and protein levels were lower in the groups that received chia compared with HFD + CC. Chia intake presented low calcium bioavailability regardless of the type of diet consumed and was able to improved inflammation and the lipid profile in young Wistar rat. Besides this, the consumption of this seed increased the activity of antioxidants enzymes.
奇亚籽是钙的良好来源，但关于其在炎症状态下的生物利用度尚未有报道。因此，本研究评估了奇亚籽对高脂饮食或标准饮食喂养 35 天的 Wistar 大鼠的钙生物利用度、炎症和氧化应激的影响。奇亚籽的摄入导致钙平衡和钙吸收及保留率降低。此外，摄入奇亚籽的大鼠的尿钙浓度降低。摄入奇亚籽的动物的骨骼阻力低于摄入碳酸钙的标准饮食喂养的大鼠。摄入奇亚籽的动物的总胆固醇、极低密度脂蛋白胆固醇和低密度脂蛋白胆固醇水平低于摄入碳酸钙的动物。与高脂肪碳酸钙组相比，标准饮食喂养的动物的血浆超氧化物歧化酶浓度更高。摄入奇亚籽的动物的 PPAR-α 蛋白水平较高，而 TNF-α 和 IL-10 水平较低。与 HFD+CC 组相比，摄入奇亚籽的动物的 NFκB mRNA 表达和蛋白水平较低。无论摄入何种饮食，奇亚籽的钙生物利用度都较低，并且能够改善年轻 Wistar 大鼠的炎症和血脂谱。此外，这种种子的摄入增加了抗氧化酶的活性。
