Institute of Medical Research, School of Medicine, University of Antioquia, Medellín, Colombia.
Group of Investigative Dermatology (GRID).
Br J Dermatol. 2019 Oct;181(4):770-777. doi: 10.1111/bjd.17742. Epub 2019 Jun 10.
In recent years, the need for international, objective, patient-reported outcomes measures has grown as international collaboration has increased. As most quality-of-life scales have been developed in English, there is a growing need to adapt them transculturally to obtain equivalence between the original instrument and the adapted scale.
To assess the construct and convergent-discriminant validity and responsiveness of the Colombian version of Skindex-29.
The cross-sectional and longitudinal validity and responsiveness were tested in both healthy and dermatology patients. Construct validity was tested through a confirmatory factor analysis. The convergent-discriminant validity was assessed by examining the Spearman correlation coefficient. Change sensitivity was tested by means of the standardized response mean. The effect size and the minimum detectable change were also assessed.
A total of 265 participants were included; 21·1% were healthy individuals, and 78·9% patients had either inflammatory or noninflammatory skin diseases. Confirmatory factor analysis showed an adequate comparative fit index and Tucker-Lewis index adjustment for the root mean square error of approximation. Convergent validity showed moderate correlations between the emotions, functioning and physical function or physical role domains. Discriminant validity showed low correlations between overall domains for both scales. Sensitivity to change at the first and third month showed effect sizes in global Skindex scores of 0·92 and 0·82, respectively.
The Colombian version of Skindex-29 is a valid and clinically sensitive instrument, which can be used for clinical practice and for research to measure the impact of skin diseases on the quality of life of dermatology patients.
近年来，随着国际合作的增加，对国际、客观、患者报告的结局测量的需求不断增长。由于大多数生活质量量表都是用英文开发的，因此越来越需要对其进行跨文化适应，以获得原始工具与改编量表之间的等效性。
评估 Skindex-29 哥伦比亚版的结构和汇聚判别效度及反应度。
在健康人群和皮肤科患者中均进行了横断面和纵向效度及反应度测试。结构效度通过验证性因子分析进行测试。汇聚判别效度通过检查斯皮尔曼相关系数进行评估。通过标准化反应均数来测试变化敏感性。还评估了效应量和最小可检测变化。
共纳入 265 名参与者；21.1%为健康个体，78.9%的患者患有炎症性或非炎症性皮肤病。验证性因子分析显示，对于近似均方根误差，根均方误差比较拟合指数和塔克-刘易斯指数调整适中。汇聚效度显示情绪、功能和身体功能或身体角色领域之间存在中度相关性。判别效度显示两个量表的总体领域之间相关性较低。在第一个月和第三个月的变化敏感性显示，全球 Skindex 评分的效应量分别为 0.92 和 0.82。
Skindex-29 哥伦比亚版是一种有效且具有临床敏感性的工具，可用于临床实践和研究，以衡量皮肤病对皮肤科患者生活质量的影响。
