Victori Pedro, Buffa Francesca M
CRUK/MRC Oxford Institute, Department of Oncology, Medical Science Division, University of Oxford , Oxford , United Kingdom.
Br J Radiol. 2019 Jan;92(1093):20180856. doi: 10.1259/bjr.20180856. Epub 2018 Nov 28.
The application of modelling to solve problems in biology and medicine, and specifically in oncology and radiation therapy, is increasingly established and holds big promise. We provide an overview of the basic concepts of the field and its current state, along with new tools available and future directions for research. We will outline radiobiology models, examples of other anticancer therapy models, multiscale modelling, and we will discuss mechanistic and phenomenological approaches to modelling.
建模在解决生物学和医学问题，特别是肿瘤学和放射治疗问题中的应用日益成熟且前景广阔。我们概述了该领域的基本概念及其当前状况，以及可用的新工具和未来的研究方向。我们将概述放射生物学模型、其他抗癌治疗模型的示例、多尺度建模，并讨论建模的机制和现象学方法。
