Agharezaee Niloofar, Hashemi Mehrdad, Shahani Minoo, Gilany Kambiz
Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
J Reprod Infertil. 2018 Oct-Dec;19(4):185-192.
Precision medicine (PM) is an approach that has the power to create the best effect and safety of medicine and treatment with the least side effects for each person. PM is very helpful as sometimes due to inaccurate or late diagnosis or toxicities of the drugs irreversible side effect for patient's health are generated. This seemingly new and emerging science is also effective in preventing disease, due to differences in the genes, environment, and lifestyles of any particular person. PM can be a prominent criterion in infertility research. To achieve this goal, there should be information from a healthy human body, including genetic and molecular information. A PM is an evolution in health care, which is very helpful even economically. The guarantor of the PM success is the examination of the molecular profile of the patient, including genes, proteins, metabolites, . Therefore, genomics, proteomics, and metabolomics-based techniques are very important in this regard. Unfortunately, despite extensive studies on PM practice in various fields, male infertility has remained unresponsive. Given that around 20% of couples around the world suffer from infertility, and almost half of them are related to men's problems, the PM approach has a high potential for male infertility. In this study, with the help of proteomics and metabolomics, PM information on male infertility was explored.
精准医学（PM）是一种能够以最小的副作用为每个人创造最佳药物疗效和安全性的治疗方法。PM非常有用，因为有时由于诊断不准确或延迟，或者药物毒性，会给患者健康带来不可逆的副作用。由于任何特定个体的基因、环境和生活方式存在差异，这种看似新兴的科学在预防疾病方面也很有效。PM可以成为不孕症研究的一个重要标准。为了实现这一目标，应该有来自健康人体的信息，包括基因和分子信息。精准医学是医疗保健领域的一次变革，甚至在经济方面也非常有益。精准医学成功的保证是对患者分子特征的检测，包括基因、蛋白质、代谢物等。因此，基于基因组学、蛋白质组学和代谢组学的技术在这方面非常重要。不幸的是，尽管在各个领域对精准医学实践进行了广泛研究，但男性不育问题仍然没有得到解决。鉴于全球约20%的夫妇患有不孕症，其中近一半与男性问题有关，精准医学方法在男性不育症方面具有很大潜力。在本研究中，借助蛋白质组学和代谢组学，探索了有关男性不育症的精准医学信息。
