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雷公藤红素抑制卵巢癌细胞的生长以及…… （原文此处不完整）

Celastrol Inhibits the Growth of Ovarian Cancer Cells and .

作者信息

Xu Li-Na, Zhao Na, Chen Jin-Yan, Ye Piao-Piao, Nan Xing-Wei, Zhou Hai-Hong, Jiang Qi-Wei, Yang Yang, Huang Jia-Rong, Yuan Meng-Ling, Xing Zi-Hao, Wei Meng-Ning, Li Yao, Shi Zhi, Yan Xiao-Jian

机构信息

Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Department of Gynecology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

出版信息

Front Oncol. 2019 Jan 28;9:2. doi: 10.3389/fonc.2019.00002. eCollection 2019.

DOI:10.3389/fonc.2019.00002
PMID:30746340
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6360154/
Abstract

Celastrol is a natural triterpene isolated from the Chinese plant Thunder God Vine with potent antitumor activity. However, the effect of celastrol on the growth of ovarian cancer cells and is still unclear. In this study, we found that celastrol induced cell growth inhibition, cell cycle arrest in G2/M phase and apoptosis with the increased intracellular reactive oxygen species (ROS) accumulation in ovarian cancer cells. Pretreatment with ROS scavenger N-acetyl-cysteine totally blocked the apoptosis induced by celastrol. Additionally, celastrol inhibited the growth of ovarian cancer xenografts in nude mice. Altogether, these findings suggest celastrol is a potential therapeutic agent for treating ovarian cancer.

摘要

雷公藤红素是从中国植物雷公藤中分离出的一种具有强大抗肿瘤活性的天然三萜。然而，雷公藤红素对卵巢癌细胞生长的影响仍不清楚。在本研究中，我们发现雷公藤红素可诱导卵巢癌细胞生长抑制、细胞周期阻滞于G2/M期并诱导凋亡，同时细胞内活性氧（ROS）积累增加。用ROS清除剂N-乙酰半胱氨酸预处理可完全阻断雷公藤红素诱导的凋亡。此外，雷公藤红素可抑制裸鼠体内卵巢癌异种移植物的生长。总之，这些发现表明雷公藤红素是治疗卵巢癌的一种潜在治疗剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f8e/6360154/abf19ccd3677/fonc-09-00002-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f8e/6360154/93b697e9d91e/fonc-09-00002-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f8e/6360154/3453b9614e9e/fonc-09-00002-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f8e/6360154/0b88461fb85a/fonc-09-00002-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f8e/6360154/ea6b81b95c7b/fonc-09-00002-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f8e/6360154/dc5e208e3d88/fonc-09-00002-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f8e/6360154/abf19ccd3677/fonc-09-00002-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f8e/6360154/93b697e9d91e/fonc-09-00002-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f8e/6360154/3453b9614e9e/fonc-09-00002-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f8e/6360154/0b88461fb85a/fonc-09-00002-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f8e/6360154/ea6b81b95c7b/fonc-09-00002-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f8e/6360154/dc5e208e3d88/fonc-09-00002-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f8e/6360154/abf19ccd3677/fonc-09-00002-g0006.jpg

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本文引用的文献

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2
Inhibition of WEE1 Suppresses the Tumor Growth in Laryngeal Squamous Cell Carcinoma.WEE1的抑制作用可抑制喉鳞状细胞癌的肿瘤生长。
Front Pharmacol. 2018 Sep 28;9:1041. doi: 10.3389/fphar.2018.01041. eCollection 2018.
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Ovarian cancer statistics, 2018.
Int J Biol Sci. 2024 Oct 7;20(14):5510-5530. doi: 10.7150/ijbs.99592. eCollection 2024.
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Regulation of Tumor Apoptosis of -Derived Lanostane Triterpenes by AKT/PI3K and MAPK Signaling Pathways .- 衍生的羊毛甾烷三萜通过 AKT/PI3K 和 MAPK 信号通路调节肿瘤细胞凋亡。
Nutrients. 2023 Oct 13;15(20):4360. doi: 10.3390/nu15204360.
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