Turk J Med Sci. 2019 Feb 11;49(1):375-383. doi: 10.3906/sag-1709-143.
BACKGROUND/AIM: Lactic acid bacteria prevent the overgrowth of pathogenic agents and opportunistic pathogens in the vagina. Moreover, lactic acid bacteria contribute to the preservation of vaginal microbiota by producing antimicrobial agents. Previous studies showed that some lactic acid bacteria exhibited antimicrobial activity against Candida species causing yeast vaginosis as well as many bacterial pathogens.
The antifungal activities of various lactic acid bacteria isolated from the vagina of healthy women on some Candida species isolated from the vagina were investigated by agar diffusion technique.
Most of the lactic acid bacteria that belong to the species of Lactobacillus crispatus, L. fermentum, L. acidophilus, L. paracesei subsp. paracesei, L. pentosus, and L. plantarum exhibited antifungal activity in varying ratios against C. albicans, C. glabrata, and C. tropicalis strains isolated from the vagina.
The lactic acid bacteria are useful microorganisms associated with a variety of probiotic properties. In this sense, our lactic acid bacteria isolates with high antifungal activity may be promising candidates as probiotic microorganisms in the inhibition of vaginal candidiasis, which is one of the most prevalent problems, or in the protection against candidiasis. We will continue our studies in this area.
背景/目的：乳酸菌可防止阴道中病原体和机会性病原体的过度生长。此外，乳酸菌通过产生抗菌剂有助于维持阴道微生物群。先前的研究表明，一些乳酸菌对引起酵母性阴道炎的念珠菌属物种以及许多细菌病原体具有抗菌活性。
通过琼脂扩散技术研究了从健康女性阴道分离的各种乳酸菌对阴道分离的某些念珠菌属物种的抗真菌活性。
大多数属于乳酸乳球菌、发酵乳杆菌、嗜酸乳杆菌、副干酪乳杆菌亚种副干酪亚种、戊糖乳杆菌和植物乳杆菌的乳酸菌对阴道分离的白色念珠菌、光滑念珠菌和热带念珠菌菌株表现出不同比例的抗真菌活性。
乳酸菌是与多种益生菌特性相关的有用微生物。从这个意义上说，我们具有高抗真菌活性的乳酸菌分离物可能是抑制阴道念珠菌病（最常见问题之一）或预防念珠菌病的有前途的益生菌微生物候选物。我们将继续在这一领域进行研究。
