Wang Helen T, Anvari Sara, Anagnostou Katherine
Department of Pediatrics, Section of Immunology, Allergy, Rheumatology, and Retrovirology, Texas Children's Hospital, Houston, TX 77030, USA.
Baylor College of Medicine, Department of Pediatrics, Section of Immunology, Allergy, Rheumatology, and Retrovirology, Houston, TX 77030, USA.
Children (Basel). 2019 Feb 5;6(2):24. doi: 10.3390/children6020024.
The prevalence of allergic disorders has been increasing worldwide and significantly impacts the quality of life of the atopic individual. There has been an increased interest in the role of probiotics for the prevention and treatment of allergic disorders, given the recent evidence that atopy risk may be associated with a dysbiosis of the gut microbiome. Research in this area is ongoing with some studies showing possible benefits of probiotics, with seemingly little to no risk. While these studies suggest that there may be a promise in probiotic use for the prevention or treatment of allergy, further evidence is needed to determine its efficacy, optimal dosing, and strains needed for treatment. In this review, we discuss recently published studies examining the benefits, risks, and role of probiotics in preventing atopic dermatitis, asthma, allergic rhinitis, and food allergy.
全球范围内，过敏性疾病的患病率一直在上升，这对特应性个体的生活质量产生了重大影响。鉴于最近有证据表明特应性风险可能与肠道微生物群失调有关，人们对益生菌在预防和治疗过敏性疾病中的作用越来越感兴趣。该领域的研究正在进行，一些研究表明益生菌可能具有益处，且似乎几乎没有风险。虽然这些研究表明益生菌在预防或治疗过敏方面可能有前景，但仍需要进一步的证据来确定其疗效、最佳剂量以及治疗所需的菌株。在这篇综述中，我们讨论了最近发表的研究，这些研究探讨了益生菌在预防特应性皮炎、哮喘、过敏性鼻炎和食物过敏方面的益处、风险及作用。
